Document Detail


Residue depletion study and withdrawal period for flunixin-N-methyl glucamine in bovine milk following intravenous administration.
MedLine Citation:
PMID:  14705899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this study was to establish a withdrawal period for flunixin in milk by quantifying 5-hydroxyflunixin, the marker residue, in bovine milk as a function of time, following intravenous treatment of lactating dairy cows with flunixin-N-methyl glucamine (Banamine or Finadyne). Lactating dairy cows were dosed on three consecutive days at 2.2 mg of flunixin free acid/kg of body weight/day. Milk was collected twice daily and assayed using a liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) procedure. The method was validated at concentrations in the range 0.5-250 ppb. The concentrations for 5-hydroxyflunixin measured 12 h after the last administration of drug ranged from 1.56 to 40.6 ppb for all cows. Milk concentrations for 5-hydroxyflunixin were used to establish withdrawal periods of 36 h using guidelines established by the U.S. Food and Drug Administration/Center for Veterinary Medicine and 24 h using guidelines established by the European Medicinal Evaluation Agency/Committee on Veterinary Medicinal Products.
Authors:
Maureen A Ngoh; Peter G Wislocki; Kenneth Thompson; Terry Katz; Allan Weingarten; Terry TerHune; Bret Hurshman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  51     ISSN:  0021-8561     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2004-01-06     Completed Date:  2005-01-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4701-7     Citation Subset:  IM    
Affiliation:
Drug Safety and Metabolism-Animal Health, Schering-Plough Research Institute, 144 Route 94 South, Lafayette, New Jersey 07848, USA. maureen.ngoh@spcorp.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*,  pharmacokinetics*
Cattle / metabolism*
Chromatography, Liquid
Clonixin / administration & dosage*,  analogs & derivatives*,  pharmacokinetics*
Drug Residues / analysis
Female
Kinetics
Lactation
Mass Spectrometry
Milk / chemistry*
Time Factors
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 17737-65-4/Clonixin; 42461-84-7/flunixin meglumine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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