Document Detail


Residuals of beta-hexachlorocyclohexane, dichlorodiphenyltrichloroethane, and hexachlorobenzene in serum, and relations with consumption of dietary components in rural residents in Japan.
MedLine Citation:
PMID:  11886087     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To estimate levels of organochlorine residuals in the Japanese population and the contribution of dietary factors to these levels, we determined serum levels of beta-hexachlorocyclohexane (beta-HCH), hexachlorobenzene (HCB), p,p'-dichlorodiphenyldichloroethane (p,p'-DDD), 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene (p,p'-DDE) and p,p'-dichlorodiphenyltrichloroethane (p,p'-DDT) in 41 volunteers (14 men and 27 women) in a rural area of Northern Japan. These organochlorine levels were measured using gas-chromatography mass-spectrometry. By a self-administered dietary history questionnaire, the usual dietary intake was estimated. Their median levels (range) were as follows: beta-HCH, 0.50 (0.05-1.50); HCB, 0.20 (0.02-0.70); and total DDT (p,p'-DDE + p,p'-DDT), 5.0 (0.9-31.0) ng/ml serum. Levels of p,p'-DDD were detected in only seven subjects (0.05-0.6 ng/ml serum). The beta-HCH levels were increased with rice and milk intakes, but the least squares means were not simply increased according to the quartile of the intakes. Concerning HCB, fish intake showed a borderline significant correlation (0.20, P = 0.052). In terms of total DDT, intakes of meat, fish, vegetable and milk showed a positive relationship, although none of them provided statistically significant results. No other statistically significant relation between any organochlorines and any food intakes examined was observed in this study. The present study suggests that organochlorine compounds are transported into the human body via foods in the Japanese population. Their effects on health should thus be investigated and monitored.
Authors:
T Hanaoka; Y Takahashi; M Kobayashi; S Sasaki; M Usuda; S Okubo; M Hayashi; S Tsugane
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Science of the total environment     Volume:  286     ISSN:  0048-9697     ISO Abbreviation:  Sci. Total Environ.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-11     Completed Date:  2002-03-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0330500     Medline TA:  Sci Total Environ     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  119-27     Citation Subset:  IM    
Affiliation:
Epidemioloy and Biostatistics Division, National Cancer Center Research Institute East, Kashiwa-shi, Chiba, Japan. thanaoka@east.ncc.go.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Animals
Diet*
Environmental Exposure*
Female
Fishes
Food Contamination
Fungicides, Industrial / blood*
Gas Chromatography-Mass Spectrometry
Hexachlorobenzene / blood*
Humans
Japan
Lindane / blood*
Male
Meat
Middle Aged
Pesticide Residues / blood*
Rural Population
Trichloroethanes / blood*
Vegetables
Chemical
Reg. No./Substance:
0/Fungicides, Industrial; 0/Pesticide Residues; 0/Trichloroethanes; 118-74-1/Hexachlorobenzene; 319-85-7/beta-hexachlorocyclohexane; 58-89-9/Lindane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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