Document Detail

Residual indocyanine green fluorescence pattern after vitrectomy for idiopathic macular hole with internal limiting membrane peeling.
MedLine Citation:
PMID:  17215268     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Internal limiting membrane (ILM) peeling with indocyanine green (ICG) staining is a commonly used procedure to treat idiopathic macular holes (MH). AIM: To report changes in the patterns of residual ICG fluorescence over time after vitrectomy using the Heidelberg Retina Angiograph 2 (HRA2, Heidelberg Engineering, Heidelberg, Germany). METHODS: 10 patients (10 eyes) who had undergone vitrectomy for MH with ILM peeling were included. 9 (90%) patients underwent ILM peeling with ICG, and 1 (10%) patient had it with triamcinolone acetonide (TA). We observed residual ICG using HRA2, postoperatively. Autofluorescence, optical coherence tomography images and best-corrected visual acuity (BCVA) measurements were also obtained. The minimal follow-up was 3 months. RESULTS: The MHs were closed postoperatively in all patients (100%). In eyes that underwent ILM peeling with ICG, the BCVA improved significantly (p<0.001) in 8 (89%) eyes and was unchanged in 1 (11%) eye. HRA2 showed the ICG fluorescence patterns but not TA postoperatively. The ICG hyperfluorescent signal was typically diffuse at the posterior retina and was hypofluorescent around the fovea. The hyperfluorescence then migrated towards the optic nerve disc presumably along the nerve fibre, and the area of ILM peeling was clearly identified. A large number of hyperfluorescent dots were observed instead of diffuse hyperfluorescence that was observed just after surgery. CONCLUSIONS: Patterns of residual ICG fluorescence were sequentially observed with HRA2 after vitrectomy for MH with ICG-assisted ILM peeling.
Kaori Sayanagi; Yasushi Ikuno; Kaori Soga; Miki Sawa; Yusuke Oshima; Motohiro Kamei; Shunji Kusaka; Yasuo Tano
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-01-10
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  91     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-19     Completed Date:  2007-07-30     Revised Date:  2010-09-15    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  939-44     Citation Subset:  IM    
Department of Ophthalmology E7, Osaka University Medical School, Suita 565-0871, Japan.
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MeSH Terms
Coloring Agents / diagnostic use,  pharmacokinetics
Epiretinal Membrane / metabolism,  surgery*
Eye / metabolism
Follow-Up Studies
Indocyanine Green / diagnostic use,  pharmacokinetics
Middle Aged
Postoperative Period
Retinal Perforations / metabolism,  surgery*
Tomography, Optical Coherence
Visual Acuity
Reg. No./Substance:
0/Coloring Agents; 3599-32-4/Indocyanine Green

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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