| Residual coronary stenosis after thrombolysis with rt-PA or streptokinase: acute results and 3 weeks follow-up. | |
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MedLine Citation:
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PMID: 3121335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ninety-one patients with acute myocardial infarction were assigned to intravenous treatment with streptokinase or rt-PA as part of the randomized trial carried out by the European Study Group for Recombinant Tissue-Type Plasminogen Activator (rt-PA). A patent coronary artery was found in 37 of 45 (82%) patients treated with rt-PA and in 27 of 46 (59%) patients treated with streptokinase 75-90 minutes after start of infusion. Patients were subsequently anticoagulated with heparin or dicoumarol up to a repeat angiography 3 weeks after the infarction. Of the 64 patients with successful reperfusion, 3 died and 3 suffered reocclusion of the vessel. Quantitative analysis of the coronary stenosis both immediately after thrombolysis and at 3 weeks follow-up was possible in 33 cases. Residual stenosis (percentage narrowing of diameter) decreased from 74 +/- 14% to 56 +/- 17% (P less than 0.05). No difference was observed between the groups of patients treated with streptokinase (74 +/- 9% to 57 +/- 12%, N = 17) and with rt-PA (74 +/- 17% to 56 +/- 21%, N = 16). Despite the significant regression, a coronary stenosis of more than 50% of the diameter persisted in 82% of the patients three weeks after the infarction. |
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Authors:
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W G Schmidt; R Uebis; R von Essen; S Effert; R Erbel; J Meyer; W Rutsch; M Schartl; H Schmutzler |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European heart journal Volume: 8 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1987 Nov |
Date Detail:
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Created Date: 1988-02-12 Completed Date: 1988-02-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1182-8 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine I, RWTH Aachen, F.R.G. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cineangiography Clinical Trials as Topic Coronary Angiography Coronary Disease / drug therapy* Follow-Up Studies Humans Middle Aged Radiographic Image Interpretation, Computer-Assisted Random Allocation Recombinant Proteins / therapeutic use Recurrence Streptokinase / therapeutic use* Tissue Plasminogen Activator / therapeutic use* Vascular Patency / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; EC 3.4.-/Streptokinase; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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