Document Detail


Residual coronary stenosis after thrombolysis with rt-PA or streptokinase: acute results and 3 weeks follow-up.
MedLine Citation:
PMID:  3121335     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ninety-one patients with acute myocardial infarction were assigned to intravenous treatment with streptokinase or rt-PA as part of the randomized trial carried out by the European Study Group for Recombinant Tissue-Type Plasminogen Activator (rt-PA). A patent coronary artery was found in 37 of 45 (82%) patients treated with rt-PA and in 27 of 46 (59%) patients treated with streptokinase 75-90 minutes after start of infusion. Patients were subsequently anticoagulated with heparin or dicoumarol up to a repeat angiography 3 weeks after the infarction. Of the 64 patients with successful reperfusion, 3 died and 3 suffered reocclusion of the vessel. Quantitative analysis of the coronary stenosis both immediately after thrombolysis and at 3 weeks follow-up was possible in 33 cases. Residual stenosis (percentage narrowing of diameter) decreased from 74 +/- 14% to 56 +/- 17% (P less than 0.05). No difference was observed between the groups of patients treated with streptokinase (74 +/- 9% to 57 +/- 12%, N = 17) and with rt-PA (74 +/- 17% to 56 +/- 21%, N = 16). Despite the significant regression, a coronary stenosis of more than 50% of the diameter persisted in 82% of the patients three weeks after the infarction.
Authors:
W G Schmidt; R Uebis; R von Essen; S Effert; R Erbel; J Meyer; W Rutsch; M Schartl; H Schmutzler
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European heart journal     Volume:  8     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1988-02-12     Completed Date:  1988-02-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1182-8     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine I, RWTH Aachen, F.R.G.
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MeSH Terms
Descriptor/Qualifier:
Cineangiography
Clinical Trials as Topic
Coronary Angiography
Coronary Disease / drug therapy*
Follow-Up Studies
Humans
Middle Aged
Radiographic Image Interpretation, Computer-Assisted
Random Allocation
Recombinant Proteins / therapeutic use
Recurrence
Streptokinase / therapeutic use*
Tissue Plasminogen Activator / therapeutic use*
Vascular Patency / drug effects
Chemical
Reg. No./Substance:
0/Recombinant Proteins; EC 3.4.-/Streptokinase; EC 3.4.21.68/Tissue Plasminogen Activator

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