| Residual beta-cell function and metabolic stability in insulin-dependent diabetes mellitus. | |
| | |
MedLine Citation:
|
PMID: 3046059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Using the modified sensitive method of measurement of urinary C-peptide immunoreactivity (CPR) excretion, we studied whether positive correlation between residual beta-cell function and metabolic consequence is present in insulin-dependent diabetes mellitus (IDDM) or not. After urinary CPR excretions were measured for 3 days in 40 IDDM, they were divided to three groups: group A, urinary CPR excretion less than 1 microgram/day (n = 16); group B, 1-4 micrograms/day (n = 15); group C, greater than or equal to 4 micrograms/day (n = 9). All subjects were treated with intensive insulin therapy for 1-2 months, and 1) fasting blood glucose (FBS) for one week, 2) 24-hr urinary sugar excretion (US) for one week, 3) M-value for daily variation of blood glucose, and 4) hemoglobin A1 (HbA1) were measured before and after intensive insulin treatment. And, we calculated mean and standard deviation (S.D.) of FBS and US. After intensive insulin therapy, a significant difference of the S.D. of FBS was seen between group A and group B (p less than 0.01). And, a significant difference of M-value was found between group A and group B (p less than 0.05). As significant differences were observed between group A and group B, which could not be divided into two groups by conventional CPR measurement, it seems likely that metabolic stability in IDDM mainly result from minimal remaining residual beta-cell function. |
| | |
Authors:
|
H Nakamura; A Takagi; A Tsuda; T Momotsu; S Ito; A Shibata |
Related Documents
:
|
18789669 - Effect of selenium on pancreatic proinflammatory cytokines in streptozotocin-induced di... 20028939 - Six months of diazoxide treatment at bedtime in newly diagnosed subjects with type 1 di... 11788369 - Physical exercise prevents the development of type 2 diabetes mellitus in psammomys obe... 2659619 - The effect of near-normoglycemic control on plasma factor viii/von willebrand factor an... 23514549 - Thyroid hormones-mediated effects of insulin on antioxidant enzymes from diabetic rat h... 3276479 - Hypoglycemic effect of opuntia streptacantha lemaire in niddm. 16856589 - Hepatitis c and diabetes mellitus. 3915269 - Effect of antiserum to monoclonal anti-islet cell surface antibody on pancreatic insuli... 4067519 - "glucose effect" and rate limiting function of uroporphyrinogen synthase on porphyrin m... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Tohoku journal of experimental medicine Volume: 155 ISSN: 0040-8727 ISO Abbreviation: Tohoku J. Exp. Med. Publication Date: 1988 May |
Date Detail:
|
Created Date: 1988-09-30 Completed Date: 1988-09-30 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0417355 Medline TA: Tohoku J Exp Med Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 71-80 Citation Subset: IM |
Affiliation:
|
First Department of Internal Medicine, Niigata University School of Medicine. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Blood Glucose / metabolism C-Peptide / urine* Diabetes Mellitus, Type 1 / metabolism, physiopathology, urine* Glycosuria / metabolism Hemoglobin A, Glycosylated / analysis Humans Insulin / administration & dosage Islets of Langerhans / physiopathology* Kidney Function Tests Middle Aged |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/C-Peptide; 0/Hemoglobin A, Glycosylated; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mutagenicity of the ash of rice straws by Ames' test.
Next Document: Spontaneous internal carotid artery dissection presenting as hypoglossal nerve palsy.