Document Detail

Residual DNA damage: what is left over and how does this determine cell fate?
MedLine Citation:
PMID:  1567676     Owner:  NLM     Status:  MEDLINE    
Radiation-induced DNA damage may remain unrepaired for a number of reasons: it may be too severe, it may be in inaccessible parts of the genome, it may be induced at critical points in the cell cycle or it may be converted into large DNA deletions. This residual damage is likely to be responsible for cell death either by physical restriction of replication or transcription or by metabolic disruption due to loss of function of critical genes. Although residual damage is important, cells may differ in their ability to tolerate it, which may be a factor that determines the relative radiosensitivity of a given cell population.
T J McMillan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of cancer (Oxford, England : 1990)     Volume:  28     ISSN:  0959-8049     ISO Abbreviation:  Eur. J. Cancer     Publication Date:  1992  
Date Detail:
Created Date:  1992-05-22     Completed Date:  1992-05-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9005373     Medline TA:  Eur J Cancer     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  267-9     Citation Subset:  IM    
Radiotherapy Research Unit, Institute of Cancer Research, Sutton, Surrey, U.K.
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MeSH Terms
Cell Cycle
Cell Survival
DNA / radiation effects
DNA Damage*
DNA Repair / physiology
Dose-Response Relationship, Drug
Reg. No./Substance:

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