| Residential pesticides and childhood leukemia: a systematic review and meta-analysis. | |
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MedLine Citation:
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PMID: 21519680 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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It is a systematic review and meta-analysis of previous observational epidemiologic studies examining the relationship between residential pesticide exposures during critical exposure time windows (preconception, pregnancy, and childhood) and childhood leukemia. Searches of Medline and other electronic databases were performed (1950-2009). Study selection, data abstraction, and quality assessment were performed by two independent reviewers. Random effects models were used to obtain summary odds ratios (ORs) and 95% confidence intervals (Cis). Of the 17 identified studies, 15 were included in the meta-analysis. Exposures during pregnancy to unspecified residential pesticides insecticides, and herbicides were positively associated with childhood leukemia. Exposures during childhood to unspecified residential pesticides and insecticides were also positively associated with childhood leukemia, but there was no association with herbicides. Positive associations were observed between childhood leukemia and residential pesticide exposures. Further work is needed to confirm previous findings based on self-report, to examine potential exposure-response relationships, and to assess specific pesticides and toxicologically related subgroups of pesticides in more detail. |
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Authors:
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Michelle C Turner; Donald T Wigle; Daniel Krewski |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Ciência & saúde coletiva Volume: 16 ISSN: 1678-4561 ISO Abbreviation: Cien Saude Colet Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-04-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9713483 Medline TA: Cien Saude Colet Country: Brazil |
Other Details:
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Languages: eng Pagination: 1915-31 Citation Subset: IM |
Affiliation:
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Centre for Population Health Risk Assessment, Institute of Population Health, University of Ottawa, Ottawa, ON, Canada, mturner@uottawa.ca. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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