Document Detail


Resident cardiomyocyte precursor stem cells in the myocardium of infants of the first two years of life with tetralogy of fallot.
MedLine Citation:
PMID:  23330114     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We studied the content of resident myocardial stem cells, cardiomyocyte precursors, in myocardial biopsy specimens from the right ventricular outflow tract of patients of the first two years of life with tetralogy of Fallot. Myocardial resident stem cells were detected by the method of confocal immunohistochemistry using antibodies to c-kit and sarcomeric α-actin. The diameter of right ventricular cardiomyocytes was measured; the presence of myolysis zones was semiquantitatively evaluated. Electron microscopic analysis of right ventricular cardiomyocytes was performed. The data on the content of resident myocardial stem cells were compared with clinical and functional parameters of the patients and morphological peculiarities of the myocardium. C-kit-positive resident myocardial stem cells were detected in the right ventricle of 17.4% patients with tetralogy of Fallot. The content of resident myocardial stem cells in these patients varied from 4 to 45 (median 11) per 1 mln cardiomyocytes; this parameter was higher in patients with high content of small cardiomyocytes (diameter <10 μ) and cardiomyocytes with incomplete myofibril assembly in the right ventricular myocardium.
Authors:
T V Sukhacheva; Yu A Chudinovskikh; M V Eremeeva; R A Serov; M V Samsonova; A L Chernyaev; A I Kim; L A Bockeria
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  154     ISSN:  1573-8221     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2013-01-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng; rus     Pagination:  158-62     Citation Subset:  IM    
Affiliation:
A. N. Bakulev Research Center of Cardiovascular Surgery, Russian Academy of Medical Sciences; Institute of Pulmonology, Federal Biomedical Agency, Moscow. tatiana@box.ru.
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