| Resident and monocyte-derived dendritic cells become dominant IL-12 producers under different conditions and signaling pathways. | |
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MedLine Citation:
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PMID: 20644172 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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IL-12 is such a pivotal cytokine that it has been called the third signal for T cell activation, TCR engagement being the first and costimulation being the second. It has been generally viewed that the resident CD8(+) dendritic cell (DC) subset is the predominant IL-12-producing cell type. In this study, we found, although this is so under steady state conditions, under inflammatory conditions monocyte-derived DC (mDC) became a major cell type producing IL-12. Depletion of either type of DC resulted in reduced production of IL-12 in vivo. For CD8(+) DC, IL-12 production could be stimulated by various pathways viz. signaling through MyD88, Trif, or nucleotide-binding oligomerization domain (Nod)-like receptors. In contrast, for mDC, IL-12 production was mainly dependent on MyD88 signaling. Thus, conventional DCs and mDCs use different pathways to regulate IL-12 production. |
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Authors:
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Yifan Zhan; Yuekang Xu; Shirley Seah; Jamie L Brady; Emma M Carrington; Christina Cheers; Ben A Croker; Li Wu; Jose A Villadangos; Andrew M Lew |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-19 |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 185 ISSN: 1550-6606 ISO Abbreviation: J. Immunol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-05 Completed Date: 2010-09-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 2125-33 Citation Subset: AIM; IM |
Affiliation:
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The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. zhan@wehi.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylmuramyl-Alanyl-Isoglutamine
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pharmacology Adaptor Proteins, Vesicular Transport / genetics, immunology, metabolism Animals CD8-Positive T-Lymphocytes / immunology, metabolism Cytokines / immunology, metabolism Dendritic Cells / drug effects, immunology*, metabolism Female Flow Cytometry Interleukin-12 / genetics, immunology*, metabolism Lipopolysaccharides / pharmacology Listeria Infections / immunology*, microbiology Listeria monocytogenes / immunology Male Membrane Glycoproteins / genetics, immunology, metabolism Mice Mice, Inbred C57BL Mice, Knockout Monocytes / immunology, metabolism Myeloid Differentiation Factor 88 / genetics, immunology, metabolism Nod2 Signaling Adaptor Protein / genetics, immunology, metabolism Poly I-C / pharmacology Reverse Transcriptase Polymerase Chain Reaction Signal Transduction / immunology* Toll-Like Receptor 7 / genetics, immunology, metabolism Toll-Like Receptor 9 / genetics, immunology, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Adaptor Proteins, Vesicular Transport; 0/Card15 protein, mouse; 0/Cytokines; 0/Lipopolysaccharides; 0/Membrane Glycoproteins; 0/Myd88 protein, mouse; 0/Myeloid Differentiation Factor 88; 0/Nod2 Signaling Adaptor Protein; 0/TICAM-1 protein, mouse; 0/Tlr7 protein, mouse; 0/Tlr9 protein, mouse; 0/Toll-Like Receptor 7; 0/Toll-Like Receptor 9; 187348-17-0/Interleukin-12; 24939-03-5/Poly I-C; 53678-77-6/Acetylmuramyl-Alanyl-Isoglutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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