| Resident B cells regulate thymic expression of myelin oligodendrocyte glycoprotein. | |
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MedLine Citation:
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PMID: 21550671 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thymic B cells represent a numerically minor cell population located primarily at the cortico-medullary junction. Their biological role is unclear. B cell-deficient μMT mice exhibited reduced medullary thymic epithelial cell (mTEC) numbers and reduced MOG and insulin mRNA expression. Lymphotoxin produced by B cells was critical for normal tissue restricted antigen (TRA) expression, suggesting that B cells regulate self-antigens through their production of LT. These results reveal an unexpected role of B cells in mTEC maintenance and expression of TRAs through their production of LT. |
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Authors:
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Eitan M Akirav; Yan Xu; Nancy H Ruddle |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-05-07 |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 235 ISSN: 1872-8421 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-09 Completed Date: 2011-08-08 Revised Date: 2011-09-08 |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 33-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals B-Lymphocyte Subsets / cytology, immunology* Female Lymphocyte Count Mice Mice, Inbred C57BL Mice, Knockout Mice, Nude Myelin-Associated Glycoprotein / biosynthesis* RNA, Messenger / antagonists & inhibitors, biosynthesis Thymus Gland / immunology, metabolism*, pathology Transplantation Chimera |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA016885-30/CA/NCI NIH HHS; R01 CA16885/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Myelin-Associated Glycoprotein; 0/RNA, Messenger; 0/myelin oligodendrocyte glycoprotein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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