| Residence time distribution of diazepam in the isolated perfused rat liver. Analysis with the axial dispersion model. | |
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MedLine Citation:
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PMID: 1302891 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The application of the axial dispersion model to diazepam hepatic elimination was evaluated using data obtained for impulse-response experiments with diazepam in the single-pass isolated perfused rat liver preparation. The transient form of the two-compartment dispersion model was applied to the output concentration versus time profile of diazepam after bolus input of a radiolabelled tracer into the hepatic portal vein (n = 4), providing DN and CLint estimates of 0.251 +/- 0.093 and 135 +/- 59 ml min-1, respectively. In contrast, the one-compartment form of the axial dispersion model, which assumes instantaneous transversal distribution of substance to the accessible spaces within the liver, could not adequately describe the residence time distribution (RTD) of diazepam. Furthermore, the magnitude of DN, a stochastic parameter which characterizes the axial spreading of solutes during transit through the liver, is similar to that determined for non-eliminated substances such as erythrocytes, albumin, sucrose and water. These findings suggest that the dispersion of diazepam in the perfused rat liver is determined primarily by the architecture of the hepatic microvasculature. |
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Authors:
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J M Díaz-García; D Fos |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Revista española de fisiología Volume: 48 ISSN: 0034-9402 ISO Abbreviation: Rev. Esp. Fisiol. Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1993-06-16 Completed Date: 1993-06-16 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0404475 Medline TA: Rev Esp Fisiol Country: SPAIN |
Other Details:
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Languages: eng Pagination: 221-9 Citation Subset: IM |
Affiliation:
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Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia Universidad de Navarra, Pamplona, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diazepam / pharmacokinetics* Liver / blood supply, metabolism* Male Models, Biological* Perfusion Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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439-14-5/Diazepam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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