| Resibufogenin Administration Prevents Oxidative Stress in a Rat Model of Human Preeclampsia. | |
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MedLine Citation:
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PMID: 21174582 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background and Objectives. Marinobufagenin (MBG) is a cardiotonic steroid that is increased in preeclampsia. An analog of MBG, resibufogenin (RBG), prevents the development of preeclampsia in a rat model. Oxidative stress is a concomitant of endothelial dysfunction in the latter disorder. The objective of the current studies was to evaluate the status of oxidative stress in a rat model of preeclampsia. Methods. We measured the aortic AT(1) receptor expression and urinary excretion of 8-isoprostane (8IP) in rats rendered "preeclamptic" and compared the findings to those obtained in normal pregnant animals, pregnant rats injected with MBG, and preeclamptic rats treated with RBG. Results. Aortic AT(1) receptor expression and the urinary excretion of 8IP were significantly augmented in "preeclamptic" and MBG-injected pregnant rats compared to normal pregnant animals. RBG prevented evidence of oxidative stress in "preeclamptic" rats. Conclusion. MBG is involved in the causation of oxidative stress in our rat model and RBG attenuates this change. |
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Authors:
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Mohammad Nasir Uddin; Enoch E Agunanne; Darijana Horvat; Jules B Puschett |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-12-21 |
Journal Detail:
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Title: Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy Volume: - ISSN: 1525-6065 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421297 Medline TA: Hypertens Pregnancy Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Medicine, Division of Nephrology and Hypertension, Texas A&M Health Science Center College of Medicine and Scott & White Memorial Hospital, Temple, TX, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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