Document Detail

Resetting of essential tremor and postural tremor in Parkinson's disease with transcranial magnetic stimulation.
MedLine Citation:
PMID:  8008009     Owner:  NLM     Status:  MEDLINE    
We studied the effects of transcranial motor cortex stimulation on the electromyographic characteristics of tremor in 9 patients with familial essential tremor and in 12 patients with postural tremor associated with Parkinson's disease. Transcranial magnetic stimulation reset both types of tremor equally. The resetting depended on the stimulus intensity, but was most closely correlated with the duration of the electromyographic silent period that followed the stimulus-induced motor evoked potential. Tremor resetting was present bilaterally even after focal, unilateral stimulation. Transcranial electrical stimulation failed to reset the tremor in either patient group. These results emphasize the role of central, intracortical structures in the generation of essential tremor and postural tremor in Parkinson's disease.
A Pascual-Leone; J Valls-Solé; C Toro; E M Wassermann; M Hallett
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Muscle & nerve     Volume:  17     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-07-19     Completed Date:  1994-07-19     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  800-7     Citation Subset:  IM    
Human Cortical Physiology Unit, Medical Neurology Branch, National Institutes of Health, Bethesda, Maryland 20892.
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MeSH Terms
Electric Stimulation / methods
Middle Aged
Parkinson Disease / physiopathology*
Transcranial Magnetic Stimulation
Tremor / physiopathology*

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