Document Detail


Reservoirs of coagulase negative staphylococci in preterm infants.
MedLine Citation:
PMID:  8777675     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This investigation was undertaken to determine the magnitude of, and interrelations between, reservoirs of coagulase negative staphylococci on infants' skin at various sites (including sites used for insertion of intravascular catheters) and in faeces during the first six months of life. Sites with large numbers of coagulase negative staphylococci were identified by sampling 16 skin sites and stools from 20 preterm neonates at 8-30 days of life. A more detailed survey of numbers and types of coagulase negative staphylococci in stool and at six skin sites of 10 preterm infants was then performed over the first six months of life. Isolates of coagulase negative staphylococci were collected and characterised by speciation, antibiotic susceptibility profiling, and plasmid restriction fragment length polymorphism analysis. Large, relatively stable reservoirs were identified in the faeces, around the ear, and in the axilla and nares. Skin on the forearm and leg, sites at which peripheral catheters are frequently sited, carried small unstable numbers of coagulase negative staphylococci, which were usually indistinguishable from coagulase negative staphylococci isolated from other body sites on the same baby. Contamination of catheter insertion sites with coagulase negative staphylococci from reservoir sites on the same baby could explain these observations. These data suggest that interventions reducing cross-contamination between sites on the same baby might be as important in preventing coagulase negative staphylococcal bacteraemias as measures taken to prevent cross infection between babies. Procedures which are likely to result in heavy coagulase negative staphylococcal contamination of the hands of healthcare staff, such as changing soiled nappies, should receive particular attention.
Authors:
K Eastick; J P Leeming; D Bennett; M R Millar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  74     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-09-19     Completed Date:  1996-09-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  F99-104     Citation Subset:  AIM; IM    
Affiliation:
Bristol Public Health Laboratory, Bristol Royal Infirmary.
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MeSH Terms
Descriptor/Qualifier:
Bacteremia / prevention & control
Carrier State
Catheters, Indwelling
Coagulase
Cross Infection / prevention & control
Disease Reservoirs
Feces / microbiology*
Humans
Infant, Newborn
Infant, Premature*
Longitudinal Studies
Skin / microbiology*
Staphylococcal Infections / prevention & control,  transmission
Staphylococcus* / enzymology
Staphylococcus epidermidis
Time Factors
Chemical
Reg. No./Substance:
0/Coagulase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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