| Reserve-driven flow control for extracorporeal life support: proof of principle. | |
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MedLine Citation:
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PMID: 20118166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extracorporeal life support systems lack volume-buffering capacity. Therefore, any decrease in venous intravascular volume available for drainage may result in acutely reduced support flow. We recently developed a method to quantify drainable volume and now conceived a reserve-driven pump control strategy, which is different from existing pressure or flow servo control schemes. Here, we give an outline of the algorithm and present animal experimental data showing proof of principle. With an acute reduction in circulatory volume (10-15%), pump flow immediately dropped from 4.1 to 1.9 l/min. Our pump control algorithm was able to restore bypass flow to 3.2 l/min (about 80% of the original level) and, thereby, reduced the duration of the low-flow condition. This demonstrates that a reserve-driven pump control strategy, based on the continuous monitoring of drainable volume, may maintain extracorporeal circulatory support flow, despite serious changes in filling conditions. |
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Authors:
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A P Simons; K D Reesink; M D Lanc?; T van der Nagel; F H van der Veen; P W Weerwind; J G Maessen |
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Publication Detail:
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Type: Journal Article Date: 2010-01-29 |
Journal Detail:
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Title: Perfusion Volume: 25 ISSN: 1477-111X ISO Abbreviation: Perfusion Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-03-11 Completed Date: 2010-06-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8700166 Medline TA: Perfusion Country: England |
Other Details:
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Languages: eng Pagination: 25-9 Citation Subset: IM |
Affiliation:
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Dept. of Cardiothoracic Surgery, Cardiovascular Research Institute Maastricht - CARIM, Maastricht University Medical Centre - MUMC, Maastricht, the Netherlands. antoinepsimons@ctc.unimaas.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Animals Blood Volume Cardiopulmonary Bypass / instrumentation, methods Computers Equipment Design Extracorporeal Circulation / instrumentation*, methods* Female Goats Hemodynamics Infusion Pumps* Life Support Care / instrumentation*, methods* Models, Animal Software |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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