| Reserve carbohydrates maintain the viability of Saccharomyces cerevisiae cells during chronological aging. | |
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MedLine Citation:
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PMID: 15013667 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glycogen and trehalose are well known to participate in many important cell functions, e.g., protection from stress factors, regulation of cell growth and division, spore formation. Since the aging is a complex process involving many aspects of cell metabolism, it was interesting to study the role of glycogen and trehalose in maintenance of viability of aging cells. We have revealed that cell aging is accompanied by an abrupt fall of glycogen and trehalose contents between the second and third weeks of aging. Simultaneously, we observed a decrease in the activity of glycolytic enzymes, phosphofructokinase and hexokinase. At the same time, the viability of aging cells abruptly declined. Although we found neither glycogen nor trehalose in the cells after the third week of aging, they remained viable for some time, apparently due to development of some compensatory metabolic pathways. In spite of this fact, complete death of the cells occurred by the eighth week of experiment, which confirmed irreplaceability of reserve carbohydrates in yeast cell metabolism. Possible reasons of the inability of aging cells to accumulate glycogen and trehalose are discussed in the work. |
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Authors:
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Victor Samokhvalov; Vladimir Ignatov; Marie Kondrashova |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Mechanisms of ageing and development Volume: 125 ISSN: 0047-6374 ISO Abbreviation: Mech. Ageing Dev. Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-03-11 Completed Date: 2004-11-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0347227 Medline TA: Mech Ageing Dev Country: Ireland |
Other Details:
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Languages: eng Pagination: 229-35 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Saratov State University, Astrakhanskaya str 83, Saratov 410026, Russia. samokhvalov@mail.ru |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carbohydrate Metabolism* Glycogen / physiology Hexokinase / metabolism Phosphofructokinases / metabolism Saccharomyces cerevisiae / growth & development*, metabolism* Trehalose / metabolism |
| Chemical | |
Reg. No./Substance:
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9005-79-2/Glycogen; 99-20-7/Trehalose; EC 2.7.1 -/Phosphofructokinases; EC 2.7.1.1/Hexokinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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