| Reserpine can confer stress tolerance and lifespan extension in the nematode C. elegans. | |
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MedLine Citation:
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PMID: 18409080 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Though the lifespan extension mechanism is partly understood from C. elegans to mice, a viable pharmacological intervention is not yet feasible. Here, we report that reserpine largely known as an antipsychotic-antihypertensive drug, can extend C. elegans lifespan. Chronic reserpine treatment from embryo stage or young adults extends the C. elegans lifespan robustly at 25 degrees C. Most importantly, the reserpine treated long lived worms are active (locomotion and pharyngeal pumping) for a long time thereby conferring high quality throughout life. Reserpine mediated lifespan extension is independent of the daf-16 pathway and partly requires serotonin. Reserpine treatment makes the worms highly thermotolerant. Thus, in addition to its known function, reserpine is able to provide stress tolerance and lifespan extension in C. elegans. |
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Authors:
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Deepti Srivastava; Upasna Arya; Thangavelu SoundaraRajan; Hemalata Dwivedi; Sandeep Kumar; Jamuna R Subramaniam |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-04-14 |
Journal Detail:
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Title: Biogerontology Volume: 9 ISSN: 1389-5729 ISO Abbreviation: Biogerontology Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-08-21 Completed Date: 2008-11-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100930043 Medline TA: Biogerontology Country: Netherlands |
Other Details:
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Languages: eng Pagination: 309-16 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acclimatization Animals Antihypertensive Agents / pharmacology Antipsychotic Agents / pharmacology Caenorhabditis elegans* / drug effects, physiology Life Expectancy Longevity / drug effects* Mice Motor Activity / drug effects Reserpine / pharmacology* Stress, Psychological* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Antipsychotic Agents; 50-55-5/Reserpine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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