Document Detail


Reserpine can confer stress tolerance and lifespan extension in the nematode C. elegans.
MedLine Citation:
PMID:  18409080     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Though the lifespan extension mechanism is partly understood from C. elegans to mice, a viable pharmacological intervention is not yet feasible. Here, we report that reserpine largely known as an antipsychotic-antihypertensive drug, can extend C. elegans lifespan. Chronic reserpine treatment from embryo stage or young adults extends the C. elegans lifespan robustly at 25 degrees C. Most importantly, the reserpine treated long lived worms are active (locomotion and pharyngeal pumping) for a long time thereby conferring high quality throughout life. Reserpine mediated lifespan extension is independent of the daf-16 pathway and partly requires serotonin. Reserpine treatment makes the worms highly thermotolerant. Thus, in addition to its known function, reserpine is able to provide stress tolerance and lifespan extension in C. elegans.
Authors:
Deepti Srivastava; Upasna Arya; Thangavelu SoundaraRajan; Hemalata Dwivedi; Sandeep Kumar; Jamuna R Subramaniam
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-04-14
Journal Detail:
Title:  Biogerontology     Volume:  9     ISSN:  1389-5729     ISO Abbreviation:  Biogerontology     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-08-21     Completed Date:  2008-11-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100930043     Medline TA:  Biogerontology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  309-16     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.
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MeSH Terms
Descriptor/Qualifier:
Acclimatization
Animals
Antihypertensive Agents / pharmacology
Antipsychotic Agents / pharmacology
Caenorhabditis elegans* / drug effects,  physiology
Life Expectancy
Longevity / drug effects*
Mice
Motor Activity / drug effects
Reserpine / pharmacology*
Stress, Psychological*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Antipsychotic Agents; 50-55-5/Reserpine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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