| Resection vs drainage in treatment of chronic pancreatitis: long-term results of a randomized trial. | |
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MedLine Citation:
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PMID: 18471517 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: Tailored organ-sparing procedures have been shown to alleviate pain and are potentially superior in terms of preservation of endocrine and exocrine function as compared with standard resection (Whipple) for chronic pancreatitis with inflammatory pancreatic head tumor. Long-term results comparing these 2 procedures have not been published so far. The aim of this study was to report on long-term results of a randomized trial comparing a classical resective procedure (pylorus-preserving Whipple) with an extended drainage procedure (Frey) for chronic pancreatitis. METHODS: All patients who participated in a previously published randomized trial on the perioperative course comparing both procedures were contacted with a standardized, validated, quality of life and pain questionnaire. Additionally, patients were seen in the outpatient clinic to assess endocrine and exocrine pancreatic function by an oral glucose tolerance test and fecal chymotrypsin test. RESULTS: There were no differences between both groups regarding quality of life, pain control, or other somatic parameters after a median of 7 years postoperatively. Correlations among continuous alcohol consumption, endocrine or exocrine pancreatic function, and pain were not found. CONCLUSIONS: Both procedures provide adequate pain relief and quality of life after long-term follow-up with no differences regarding exocrine and endocrine function. However, short-term results favor the organ-sparing procedure. |
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Authors:
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Tim Strate; Kai Bachmann; Philipp Busch; Oliver Mann; Claus Schneider; Jens P Bruhn; Emre Yekebas; Thomas Kuechler; Christian Bloechle; Jakob R Izbicki |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2008-03-04 |
Journal Detail:
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Title: Gastroenterology Volume: 134 ISSN: 1528-0012 ISO Abbreviation: Gastroenterology Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-12 Completed Date: 2008-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: United States |
Other Details:
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Languages: eng Pagination: 1406-11 Citation Subset: AIM; IM |
Affiliation:
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Department of General Surgery, University Hospital Hamburg Eppendorf, Hamburg, Germany. strate@uke.uni-hamburg.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Glucose / metabolism Chymotrypsin / metabolism Drainage / methods* Feces / chemistry Female Follow-Up Studies Germany / epidemiology Humans Male Middle Aged Pancreaticoduodenectomy / methods* Pancreatitis, Chronic / metabolism, mortality, surgery* Quality of Life Questionnaires Retrospective Studies Survival Rate / trends Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; EC 3.4.21.1/Chymotrypsin |
| Comments/Corrections | |
Comment In:
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Gastroenterology. 2008 May;134(5):1605-7
[PMID:
18471528
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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