| Researches on antibacterial and antifungal agents. I. Analogs of nalidixic acid with a pyrrole moiety. | |
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MedLine Citation:
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PMID: 6861999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The synthesis and antibacterial activities of 4-hydroxyquinoline-3-carboxylic acid and 1,4-dihydro-1-ethyl-4-oxoquinoline-3-carboxylic acid containing a pyrrole or 2,5-dimethylpyrrole group at 6 position are reported. Reaction of 1-(4-aminophenyl)pyrrole or 2,5-dimethyl-1-(4-aminophenyl)-pyrrole with ethoxymethylenemalonate diethyl ester (EMME) afforded the related pyrroleanilinomethylenemalonates, which were subjected to thermal cyclization to give the required quinoline derivatives. These compounds on ethylation furnished at last the quinolonecarboxylic analogs of nalidixic acid. |
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Authors:
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F Corelli; S Massa; G Stefancich; M Artico; S Panico; N Simonetti |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Il Farmaco; edizione scientifica Volume: 38 ISSN: 0430-0920 ISO Abbreviation: Farmaco Sci Publication Date: 1983 Apr |
Date Detail:
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Created Date: 1983-08-11 Completed Date: 1983-08-11 Revised Date: 2009-06-05 |
Medline Journal Info:
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Nlm Unique ID: 0370716 Medline TA: Farmaco Sci Country: ITALY |
Other Details:
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Languages: eng Pagination: 219-31 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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chemical synthesis* Antifungal Agents / chemical synthesis* Bacteria / drug effects Chemical Phenomena Chemistry Nalidixic Acid / analogs & derivatives*, chemical synthesis, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Antifungal Agents; 389-08-2/Nalidixic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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