| Research review: a neuroscience framework for pediatric anxiety disorders. | |
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MedLine Citation:
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PMID: 17593144 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Across a range of mammalian species, early developmental variations in fear-related behaviors constrain patterns of anxious behavior throughout life. Individual differences in anxiety among rodents and non-human primates have been shown to reflect early-life influences of genes and the environment on brain circuitry. However, in humans, the manner in which genes and the environment developmentally shape individual differences in anxiety and associated brain circuitry remains poorly specified. The current review presents a conceptual framework that facilitates clinical research examining developmental influences on brain circuitry and anxiety. Research using threat-exposure paradigms might most directly integrate basic and clinical perspectives on pediatric anxiety. |
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Authors:
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Daniel S Pine |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of child psychology and psychiatry, and allied disciplines Volume: 48 ISSN: 0021-9630 ISO Abbreviation: J Child Psychol Psychiatry Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-26 Completed Date: 2007-08-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375361 Medline TA: J Child Psychol Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 631-48 Citation Subset: IM |
Affiliation:
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Section on Development and Affective Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA. daniel.pine@nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Amygdala / physiopathology* Anxiety Disorders / physiopathology* Attention / physiology Child Fear Happiness Humans Magnetic Resonance Imaging Memory / physiology Nerve Net / physiopathology* Neurosciences / methods* Phenotype Prefrontal Cortex / physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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