| Research progress on interleukin-33 and its roles in the central nervous system. | |
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MedLine Citation:
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PMID: 21934731 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Interleukin-33 (IL-33), a newly recognized IL-1 family member, is expressed by various tissues and cells. Since it can combine with chromosomes, IL-33 is regarded as an intracellular transcription repressor. Upon proinflammatory stimulation, it is released as an extracellular cytokine to function as an alarmin to dangerous signals. The IL-33 receptor is a heterodimer complex composed of ST2 and the IL-1 receptor accessory protein, the latter being conserved in other IL-1 family members. The IL-33/ST2 signaling pathway plays critical roles in inflammatory and immune diseases, as well as in central nervous system (CNS) diseases. Recently, there has been an increasing focus on IL-33, particularly on its production and functions in the CNS. The present review mainly focuses on progress in research on IL-33, especially its roles in the CNS. |
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Authors:
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Ping Han; Wen-Li Mi; Yan-Qing Wang |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroscience bulletin Volume: 27 ISSN: 1995-8218 ISO Abbreviation: Neurosci Bull Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101256850 Medline TA: Neurosci Bull Country: China |
Other Details:
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Languages: eng Pagination: 351-7 Citation Subset: IM |
Affiliation:
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Department of Integrative Medicine and Neurobiology, Institute of Acupuncture Research, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai 200032, China; E-mail: wenlimi@fudan.edu.cn. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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