| Research note: effects of age and immunization interval on the anamnestic response to T-cell-dependent and T-cell-independent antigens in chickens. | |
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MedLine Citation:
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PMID: 1754551 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Measurement of a humoral anamnestic response is a common procedure used to evaluate immunological competence. The purposes of the present study were to determine the optimum time period between primary and secondary immunizations needed to obtain the maximum antibody titer and to determine whether this interval differs with the age of the chicken or with the type of inducing antigen. The anamnestic responses of birds of two ages to a T-cell-dependent antigen (SRBC) and to a T-cell-independent antigen (Brucella abortus, BA) were evaluated. Birds of 4 wk or 6 mo of age were injected i.v. with either BA or SRBC, and a secondary injection was given 2, 4, 6, or 8 wk later. Agglutination titers for total and mercaptoethanol (ME)-resistant antibodies were determined from serum samples collected at 3, 6, and 9 days postsecondary immunization. Generally, titers were highest at 6 days postsecondary immunization. For both antigens, the chick total antibody levels at Day 6 postsecondary immunization were higher at 4-, 6-, and 8-wk immunization intervals than at 2-wk intervals; adult titers were independent of immunization interval. There was an interaction between age of birds and type of antigen. |
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Authors:
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P L Munns; S J Lamont |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Poultry science Volume: 70 ISSN: 0032-5791 ISO Abbreviation: Poult. Sci. Publication Date: 1991 Nov |
Date Detail:
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Created Date: 1992-01-29 Completed Date: 1992-01-29 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0401150 Medline TA: Poult Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2371-4 Citation Subset: IM |
Affiliation:
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Department of Animal Science, Iowa State University, Ames 50011. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Agglutination Tests Aging / immunology* Animals Antibodies, Bacterial / biosynthesis Antibody Formation* Brucella abortus / immunology Chickens / immunology* Female Hemagglutination Tests Immunization / veterinary* Immunization, Secondary / veterinary Male T-Lymphocytes / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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