Document Detail


Research methodology: cancer cachexia syndrome.
MedLine Citation:
PMID:  15332419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cachexia is a syndrome and therefore does not have a specific definition. Patients are characterized by the presence of anorexia, early satiety, weight loss, weakness, anaemia and oedema. These features occur to a variable extent in different patients and may change in severity during the course of a patient's illness. The multifactorial origin of cachexia precludes a uniform pathophysiological definition. Taken together these factors have hindered clinical studies both at a fundamental level and in terms of the introduction of effective therapy. The advent of novel therapeutic targets (e.g., ubiquitin-proteasome pathway) and biological response modifiers has opened possibilities for new clinical trials in cachexia. Regulatory authorities feel it is important not only to demonstrate efficacy in terms of patients' nutritional status (e.g., lean body mass) but also functional status (e.g., performance status). This article reviews current methods to assess the latter. Methods focused on measuring physical activity level (e.g., doubly labelled water technique or physical activity meters) promise objective data which can be readily interpreted in terms of clinically meaningful benefit.
Authors:
Max Dahele; K C H Fearon
Related Documents :
15470799 - Cardiovascular risk factors in outpatients with bipolar disorder.
3693789 - Psychoanalytic observations on the effect of lithium on manic attacks.
9840319 - Study on nutritional status of maintenance hemodialysis patients.
9085449 - Hyperparathyroidism during lithium therapy. two new cases.
646909 - Height and weight gain after total correction of fallot's tetralogy.
22572859 - Activated innate immunity and the involvement of cx3cr1-fractalkine in promoting hematu...
20618689 - Cytokine profiles of bronchoalveolar lavage fluid in patients with pneumocystis pneumonia.
24672719 - Elevated heparin-induced antibodies are more common in diabetic patients with vascular ...
109579 - Presence of free light chains in urine of patients suffering from subacute sclerosing p...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Palliative medicine     Volume:  18     ISSN:  0269-2163     ISO Abbreviation:  Palliat Med     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-08-30     Completed Date:  2004-11-02     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8704926     Medline TA:  Palliat Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  409-17     Citation Subset:  IM    
Affiliation:
Max Dahele and KCH Fearon Clinical and Surgical Sciences (Surgery), The University of Edinburgh, Royal Infirmary, Edinburgh, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Ambulatory Care
Biomedical Research / methods*
Body Composition
Cachexia / etiology*
Exercise / physiology
Humans
Neoplasms / complications*
Nutritional Status
Placebo Effect
Prognosis
Quality of Life
Weight Gain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Is there such a thing as a good death?
Next Document:  Systematic review of bisphosphonates for hypercalcaemia of malignancy.