Document Detail

Research methodology: cancer cachexia syndrome.
MedLine Citation:
PMID:  15332419     Owner:  NLM     Status:  MEDLINE    
Cachexia is a syndrome and therefore does not have a specific definition. Patients are characterized by the presence of anorexia, early satiety, weight loss, weakness, anaemia and oedema. These features occur to a variable extent in different patients and may change in severity during the course of a patient's illness. The multifactorial origin of cachexia precludes a uniform pathophysiological definition. Taken together these factors have hindered clinical studies both at a fundamental level and in terms of the introduction of effective therapy. The advent of novel therapeutic targets (e.g., ubiquitin-proteasome pathway) and biological response modifiers has opened possibilities for new clinical trials in cachexia. Regulatory authorities feel it is important not only to demonstrate efficacy in terms of patients' nutritional status (e.g., lean body mass) but also functional status (e.g., performance status). This article reviews current methods to assess the latter. Methods focused on measuring physical activity level (e.g., doubly labelled water technique or physical activity meters) promise objective data which can be readily interpreted in terms of clinically meaningful benefit.
Max Dahele; K C H Fearon
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Palliative medicine     Volume:  18     ISSN:  0269-2163     ISO Abbreviation:  Palliat Med     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-08-30     Completed Date:  2004-11-02     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8704926     Medline TA:  Palliat Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  409-17     Citation Subset:  IM    
Max Dahele and KCH Fearon Clinical and Surgical Sciences (Surgery), The University of Edinburgh, Royal Infirmary, Edinburgh, UK.
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MeSH Terms
Ambulatory Care
Biomedical Research / methods*
Body Composition
Cachexia / etiology*
Exercise / physiology
Neoplasms / complications*
Nutritional Status
Placebo Effect
Quality of Life
Weight Gain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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