Document Detail

Research issues and ethnic implications in essential hypertension.
MedLine Citation:
PMID:  1811821     Owner:  NLM     Status:  MEDLINE    
Traditional discussion of the etiology of essential hypertension has often included renal, neural, familial, and genetic theories as well as dietary salt intake. Recent findings suggest a prominent role for abnormal cation metabolism, impaired membrane transport systems, hyperinsulinemia, and psychosocial and behavioral factors. These recent advances in hypertension research suggest that a variety of interrelated factors lead to common pathways for the development and maintenance of hypertension and that a single cause of essential hypertension is less likely. A survey of these hypotheses is presented, and those that seem most likely to lead to common pathways for hypertensive phenomena or underlie established ethnic differences in hypertension are discussed in detail. The future application of molecular genetics and biochemistry of vascular and cardiac myocyte growth to hypertension epidemiology holds great promise for understanding the etiology and course of essential hypertension.
G A Mensah
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of the Association for Academic Minority Physicians : the official publication of the Association for Academic Minority Physicians     Volume:  2     ISSN:  1048-9886     ISO Abbreviation:  J Assoc Acad Minor Phys     Publication Date:  1991  
Date Detail:
Created Date:  1992-06-05     Completed Date:  1992-06-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9113765     Medline TA:  J Assoc Acad Minor Phys     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  168-73     Citation Subset:  IM    
Division of Cardiology, New York Hospital-Cornell Medical Center, New York.
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MeSH Terms
African Continental Ancestry Group*
Calcium / metabolism
Hypertension / etiology*,  genetics,  physiopathology
Insulin / blood
Insulin Resistance
Kidney / physiopathology
Sodium / metabolism
Sodium Chloride
Reg. No./Substance:
11061-68-0/Insulin; 7440-23-5/Sodium; 7440-70-2/Calcium; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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