Document Detail

Research in practice: diagnosis of subepidermal autoimmune bullous disorders.
MedLine Citation:
PMID:  19192160     Owner:  NLM     Status:  MEDLINE    
Subepidermal autoimmune bullous disorders are a heterogeneous group of diseases that are associated with autoantibodies to hemidesmosomal proteins (pemphigoid group, epidermolysis bullosa acquisita) or epidermal/tissue transglutaminase (dermatitis herpetiformis). Characterization of the target antigens has led to the description of novel entities such as anti-p200 pemphigoid and has greatly facilitated the diagnosis of these diseases. Precise identification of target antigens is of therapeutic relevance since treatment options may greatly differ between these disorders. By the use of various in vitro and in vivo systems, the pathogenic relevance of autoantibodies to different hemidesmosomal constituents, including BP180 (type XVII collagen), laminin 332 (laminin 5), alpha6beta4 integrin, and type VII collagen has been demonstrated. The translation of this basic scientific work has subsequently led to the development of specific autoantibody detection systems that are not only of diagnostic use but also allow the monitoring of circulating autoantibody levels during the course of the disease and thus are helpful in guiding treatment decisions in these patients.
Enno Schmidt; Detlef Zillikens
Publication Detail:
Type:  Journal Article; Review     Date:  2009-01-22
Journal Detail:
Title:  Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG     Volume:  7     ISSN:  1610-0387     ISO Abbreviation:  J Dtsch Dermatol Ges     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-06-08     Completed Date:  2009-08-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101164708     Medline TA:  J Dtsch Dermatol Ges     Country:  Germany    
Other Details:
Languages:  eng; ger     Pagination:  296-300     Citation Subset:  IM    
Department of Dermatology, Allergy and Venereology, University of Lübeck, Germany.
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MeSH Terms
Autoimmune Diseases / diagnosis*,  immunology*
Biomedical Research / trends*
Immunoassay / methods*
Models, Immunological*
Skin Diseases, Vesiculobullous / diagnosis*,  immunology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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