Document Detail


Research in practice: Regulatory T cells - targets for therapeutic approaches?
MedLine Citation:
PMID:  21166772     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Regulatory T cells (Tregs) are essential for induction and maintenance of immunological tolerance. They contribute to prevention of autoimmunity by control and modulation of immune responses. The prevalence of autoimmune diseases, chronic infections, cancer and allergies has markedly increased in the last decades. In additions the treatment of these disorders is often unsatisfactory so that improvements are needed. This has stimulated intensive research in the biology of Tregs. Recent studies revealed that naturally occurring CD4(+) CD25(+) Tregs (nTregs) and induced Tregs (iTregs) are critical for the control of inadequate immune reactions. In humans, various iTreg populations are generated to inhibit naïve as well as activated effector T cells. Key molecules of signal transduction, essential for suppressor function of iTregs, have been identified and may be target molecules to modulate the activity of suppressor T cells with novel biologicals. Precise insight into the properties of Tregs may contribute to the development of innovative therapeutic approaches which directly affect Tregs in patients or use adoptive transfer of Tregs.
Authors:
Helmut Jonuleit; Andrea Tuettenberg; Kerstin Steinbrink;
Publication Detail:
Type:  Journal Article     Date:  2010-09-07
Journal Detail:
Title:  Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG     Volume:  9     ISSN:  1610-0387     ISO Abbreviation:  J Dtsch Dermatol Ges     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101164708     Medline TA:  J Dtsch Dermatol Ges     Country:  Germany    
Other Details:
Languages:  eng; ger     Pagination:  8-11     Citation Subset:  IM    
Copyright Information:
© The Authors • Journal compilation © Blackwell Verlag GmbH, Berlin.
Affiliation:
Department of Dermatology, University Medical Center Mainz, Germany.
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