| Research in practice: Different dendritic cell types in skin with various functions - important implications for intradermal vaccines. | |
| | |
MedLine Citation:
|
PMID: 21539709 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
It was long believed that epidermal Langerhans cells (LC) are responsible for the initiation of cellular immunity. Only recently it has been shown that in skin alone 5 different subtypes of dendritic cells (DC) can be identified. Among these, LC, but also two Langerin-expressing dermal DC populations and two more Langerin-negative DC subtypes exist. Novel findings in the model disease leishmaniasis, as well as evidence from research in contact hypersensitivity, have revealed that activation of LC in skin leads to induction of regulatory, immunosuppressive T cells, whereas the other skin DC subtypes stimulate effector T cells. Thus, when producing vaccines designed for intradermal use, it would seem advisable to attempt to activate dermal DC subtypes while avoiding activation of epidermal LC. |
| | |
Authors:
|
Esther von Stebut |
Related Documents
:
|
12744939 - Glucosamine and chondroitin sulfate: biological response modifiers of chondrocytes unde... 17107669 - Puma is critical for neonatal cardiomyocyte apoptosis induced by endoplasmic reticulum ... 17338909 - Surgical stress response. 15778979 - Endogenously expressed estrogen receptors mediate neuroprotection in hippocampal cells ... 18227389 - Signal transducer and activator of transcription-1 is critical for apoptosis in macroph... 17400209 - Sympathetic nervous system mediates surgical trauma stress-induced splenocyte apoptosis... 12165079 - Granulocyte macrophage colony stimulating factor is elevated in alveolar macrophages fr... 21960549 - Pneumocystis elicits a stat6-dependent strain specific innate immune response and airwa... 21784069 - Cd11d integrin blockade reduces the systemic inflammatory response syndrome after spina... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-3 |
Journal Detail:
|
Title: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG Volume: - ISSN: 1610-0387 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-5-4 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101164708 Medline TA: J Dtsch Dermatol Ges Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© The Authors • Journal compilation © Blackwell Verlag GmbH, Berlin. |
Affiliation:
|
Department of Dermatology, University of Mainz, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Animal-type melanoma - tumor cell invasion of dermal lymphatics and molecular identification of lymp...
Next Document: Delirium in older adults attending adult day care and family caregiver distress.