Document Detail


Research Spotlight: Nanomedicines for HIV therapy.
MedLine Citation:
PMID:  23343155     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Heterogeneity in response to HIV treatments has been attributed to several causes including variability in pharmacokinetic exposure. Nanomedicine applications have a variety of advantages compared with traditional formulations, such as the potential to increase bioavailability and specifically target the site of action. Our group is focusing on the development of nanoformulations using a closed-loop design process in which nanoparticle optimization (disposition, activity and safety) is a continuous process based on experimental pharmacological data from in vitro and in vivo models. Solid drug nanoparticles, polymer-based drug-delivery carriers as well as nanoemulsions are nanomedicine options with potential application to improve antiretroviral deployment.
Authors:
Marco Siccardi; Philip Martin; Tom O McDonald; Neill J Liptrott; Marco Giardiello; Steve Rannard; Andrew Owen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Therapeutic delivery     Volume:  4     ISSN:  2041-5990     ISO Abbreviation:  Ther Deliv     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101538870     Medline TA:  Ther Deliv     Country:  England    
Other Details:
Languages:  eng     Pagination:  153-6     Citation Subset:  IM    
Affiliation:
Department of Molecular & Clinical Pharmacology, University of Liverpool, Liverpool, UK.
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