Document Detail

Research Spotlight: Nanomedicines for HIV therapy.
MedLine Citation:
PMID:  23343155     Owner:  NLM     Status:  In-Data-Review    
Heterogeneity in response to HIV treatments has been attributed to several causes including variability in pharmacokinetic exposure. Nanomedicine applications have a variety of advantages compared with traditional formulations, such as the potential to increase bioavailability and specifically target the site of action. Our group is focusing on the development of nanoformulations using a closed-loop design process in which nanoparticle optimization (disposition, activity and safety) is a continuous process based on experimental pharmacological data from in vitro and in vivo models. Solid drug nanoparticles, polymer-based drug-delivery carriers as well as nanoemulsions are nanomedicine options with potential application to improve antiretroviral deployment.
Marco Siccardi; Philip Martin; Tom O McDonald; Neill J Liptrott; Marco Giardiello; Steve Rannard; Andrew Owen
Related Documents :
24766845 - Suppressive drug interactions between antifungals.
1396535 - Cognitive effects of oxcarbazepine and phenytoin monotherapy in newly diagnosed epileps...
9153725 - A naturalistic study of the use of vigabatrin, lamotrigine and gabapentin in adults wit...
23188105 - Prevalence of transmitted hiv-1 drug resistance mutations in children and adolescents i...
1647395 - Evidence that estramustine binds map-1a to inhibit type iv collagenase secretion.
16984215 - Prediction of in vivo drug-drug interactions from in vitro data : factors affecting pro...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Therapeutic delivery     Volume:  4     ISSN:  2041-5990     ISO Abbreviation:  Ther Deliv     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101538870     Medline TA:  Ther Deliv     Country:  England    
Other Details:
Languages:  eng     Pagination:  153-6     Citation Subset:  IM    
Department of Molecular & Clinical Pharmacology, University of Liverpool, Liverpool, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Conference report: 1st medicon valley inhalation symposium.
Next Document:  Nanomedicine for uterine leiomyoma therapy.