| Research Spotlight: Nanomedicines for HIV therapy. | |
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MedLine Citation:
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PMID: 23343155 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Heterogeneity in response to HIV treatments has been attributed to several causes including variability in pharmacokinetic exposure. Nanomedicine applications have a variety of advantages compared with traditional formulations, such as the potential to increase bioavailability and specifically target the site of action. Our group is focusing on the development of nanoformulations using a closed-loop design process in which nanoparticle optimization (disposition, activity and safety) is a continuous process based on experimental pharmacological data from in vitro and in vivo models. Solid drug nanoparticles, polymer-based drug-delivery carriers as well as nanoemulsions are nanomedicine options with potential application to improve antiretroviral deployment. |
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Authors:
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Marco Siccardi; Philip Martin; Tom O McDonald; Neill J Liptrott; Marco Giardiello; Steve Rannard; Andrew Owen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Therapeutic delivery Volume: 4 ISSN: 2041-5990 ISO Abbreviation: Ther Deliv Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101538870 Medline TA: Ther Deliv Country: England |
Other Details:
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Languages: eng Pagination: 153-6 Citation Subset: IM |
Affiliation:
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Department of Molecular & Clinical Pharmacology, University of Liverpool, Liverpool, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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