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Rescue intracytoplasmic sperm injection: a prospective randomized study.
MedLine Citation:
PMID:  22010525     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVE: To determine the optimum rescue time by comparison of results of rescue intracytoplasmic sperm injection (ICSI).
STUDY DESIGN: A total of 112 couples of total fertilization failure, who had retrieved at least four mature oocytes, were prospectively randomized into two groups: the earlier rescue group, rescue ICSI performed between 4 and 6 hours after insemination, and the control group, rescue ICSI performed between 6 and 8 hours after insemination.
RESULTS: There were no statistically significant differences in woman's age, duration of infertility, number of oocytes retrieved every cycle, and number of embryos transferred every cycle between the two groups. The normal fertilization rate of the earlier rescue group was increased compared with that of control group (63.1% vs. 55.7%, p < 0.05), whereas the abnormal fertilization rate in the earlier rescue group was decreased compared with control group (3.5% vs. 6.2%, p < 0.05). There was a trend suggesting an increase in the clinical pregnancy rate and implantation rate in the earlier rescue group compared with control group, though this failed to be significantly different.
CONCLUSION: Rescue ICSI is an effective method of eliminating totalfertilization failure. Rescue ICSI performed earlier could result in a better pregnancy rate in this select group of patients.
Authors:
Lixia Zhu; Qingsong Xi; Rui Nie; Wen Chen; Hanwang Zhang; Yufeng Li
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  56     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:    2011 Sep-Oct
Date Detail:
Created Date:  2011-10-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  410-4     Citation Subset:  IM    
Affiliation:
Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095 Jiefang Road, Wuhan 430030, People's Republic of China.
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