Document Detail

Rescue from dwarfism by thyroid function compensation in rdw rats.
MedLine Citation:
PMID:  16365524     Owner:  NLM     Status:  MEDLINE    
The rdw rat was initially reported as having hereditary dwarfism caused by pituitary dysfunction. Subsequent studies on the rdw rat, however, have demonstrated that the primary cause of rdw dwarfism is present in the thyroid gland but not in the pituitary gland. The primary cause of rdw rat disorders is a missense mutation of the thyroglobulin (Tg) gene by a one-point mutation. In the present study, we attempted to rescue the dwarfism of the rdw rats using a diet supplemented with thyroid powder (T-powder) and a thyroid graft (T-graft). The infants of the rdw rat were successfully raised to a mature stage body weight, accompanied by elevation of serum growth hormone (GH) and prolactin (PRL), by the T-powder. Furthermore, the T-graft successfully increased the body weight with fertility. The serum GH and PRL levels in the T-graft rdw rat significantly increased. The serum thyroid-stimulating hormone (TSH) levels in the T-graft rdw rat were significantly decreased but were significantly higher than those in the control rat. The GH and PRL mRNA expression in the rdw rat with the T-graft was virtually the same as that of the control, but the TSH beta mRNA differed from that of the control rats. Thus, the dwarfism in the rdw rat is rescued by thyroid function compensation, such as that afforded by T-powder and T-graft.
Sen-ichi Furudate; Masao Ono; Keiko Shibayama; Yoshihide Ohyama; Masahiro Kuwada; Toshimi Kimura; Toru Kameya
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental animals / Japanese Association for Laboratory Animal Science     Volume:  54     ISSN:  1881-7122     ISO Abbreviation:  Exp. Anim.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-12-20     Completed Date:  2009-03-19     Revised Date:  2014-10-24    
Medline Journal Info:
Nlm Unique ID:  9604830     Medline TA:  Exp Anim     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  455-60     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn
Body Weight / drug effects,  genetics
Disease Models, Animal
Dwarfism, Pituitary / genetics,  metabolism,  therapy*
Gene Expression / drug effects
Growth Hormone / blood,  genetics
Prolactin / blood,  genetics
RNA, Messenger / metabolism
Rats, Mutant Strains
Rats, Wistar
Thyroid (USP) / therapeutic use*
Thyroid Gland / metabolism,  transplantation*
Thyrotropin, beta Subunit / blood,  genetics
Reg. No./Substance:
0/RNA, Messenger; 0/Thyroid (USP); 0/Thyrotropin, beta Subunit; 9002-62-4/Prolactin; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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