Document Detail

Rescue of corpus luteum function with peri-ovulatory HCG supplementation in IVF/ICSI GnRH antagonist cycles in which ovulation was triggered with a GnRH agonist: a pilot study.
MedLine Citation:
PMID:  16895629     Owner:  NLM     Status:  MEDLINE    
Previous studies found a poor clinical outcome when a GnRH agonist (GnRHa) was used to trigger ovulation in GnRH antagonist IVF/ICSI cycles. This study aimed to determine the clinical and endocrine effects as well the optimal timing of HCG supplementation. Forty-five normogonadotrophic IVF/ICSI patients following a flexible antagonist protocol were prospectively randomized (sealed envelopes) to triggering of ovulation with a single bolus of either 10,000 IU of HCG (group 1, n = 15) or 0.5 mg buserelin s.c. In addition, the GnRHa triggered group was randomized into two groups: group 2 (n = 17) was supplemented with HCG 1500 IU, 12 h after ovulation induction and group 3 (n = 13) was supplemented with HCG 1500 IU 35 h after ovulation induction. Group 1 and group 3 had significantly higher luteal phase concentrations of progesterone (P < 0.001) as compared with group 2. Moreover, the clinical pregnancy rate of groups 1 and 3 was similar and significantly higher (P < 0.02) than that of group 2. A larger study, however, is required to substantiate these differences. No differences were seen regarding mid-luteal inhibin A concentrations between the three groups. Triggering of ovulation with GnRHa supplemented with 1500 IU HCG 35 h later (group 3) seems to secure a normal luteal phase and a normal clinical pregnancy outcome.
P Humaidan; L Bungum; M Bungum; C Yding Andersen
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  13     ISSN:  1472-6483     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-09     Completed Date:  2006-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  173-8     Citation Subset:  IM    
The Fertility Clinic, Viborg Hospital (Skive), DK 7800 Skive, Denmark.
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MeSH Terms
Chorionic Gonadotropin / administration & dosage,  therapeutic use*
Corpus Luteum / drug effects*,  physiology
Fertility Agents, Female / administration & dosage,  therapeutic use*
Fertilization in Vitro*
Gonadotropin-Releasing Hormone / administration & dosage,  agonists*,  analogs & derivatives,  antagonists & inhibitors*,  therapeutic use
Infertility, Female / drug therapy
Inhibins / blood
Ovulation / drug effects*
Ovulation Induction*
Pilot Projects
Pregnancy Rate
Progesterone / blood
Sperm Injections, Intracytoplasmic
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Fertility Agents, Female; 0/inhibin A; 33515-09-2/Gonadotropin-Releasing Hormone; 57-83-0/Progesterone; 57285-09-3/Inhibins; 79561-22-1/LHRH, Ala(6)-Gly(10)-ethylamide-

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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