| Rescue by birth: defective placental maturation and late fetal mortality. | |
| | |
MedLine Citation:
|
PMID: 11275018 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To estimate the incidence and lethality of placental maturation defect, and to determine the impact of the pattern of placental dysfunction on the risk of recurrent stillbirth or maternal disease in later life. METHODS: Questionnaire and archival analysis of fetal deaths from placental dysfunction at 32-42 weeks (1975-1995 in Zurich), classified as chronic (parenchyma loss) or acute (maturation defect of the terminal chorionic villi). Population survey of 17,415 consecutive unselected singleton placentas (1994-1998 in Berlin). RESULTS: Of the 71 stillbirths, 34 were due to parenchyma loss and 37 to maturation defect. Parenchyma loss predominated in the first pregnancy (73.5% compared with 43.2%; P <.05). The risks of recurrent stillbirth and subsequent childlessness did not differ between the two groups. Eleven percent of mothers whose placenta had maturation defect had diabetes in the index pregnancy; none of the other women in the group developed diabetes over the 5-20-year observation period. In the population survey, incidence of maturation defect was 5.7%, and was associated with fetal death in 2.3% of cases. Normal placentas were associated with fetal death in 0.033%. CONCLUSION: Placental maturation defect can be a cause of fetal hypoxia. Although the risk of stillbirth is 70-fold that of a normal placenta, few affected fetuses actually die. The risk of recurrent stillbirth is tenfold above baseline and occurs mostly after 35 weeks' gestation. |
| | |
Authors:
|
T Stallmach; G Hebisch; K Meier; J W Dudenhausen; M Vogel |
Related Documents
:
|
3024688 - Assessment of the datex relaxograph during anaesthesia and atracurium-induced neuromusc... 12499668 - Variability of autogamy-maturation pattern in genetically identical populations of para... 3946508 - Amniotic fluid phosphatidylglycerol and phosphatidylcholine phosphorus as predictors of... 3777858 - Functional phospholipid/sphingomyelin ratio: an easy to interpret indicator of fetal lu... 10206198 - Does ovulation induction affect the pregnancy rate after laparoscopic treatment of endo... 8194628 - Inhibition of angiotensin-converting enzyme--a new concept of medical treatment of male... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Obstetrics and gynecology Volume: 97 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2001 Apr |
Date Detail:
|
Created Date: 2001-03-29 Completed Date: 2001-04-26 Revised Date: 2009-10-26 |
Medline Journal Info:
|
Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
|
Languages: eng Pagination: 505-9 Citation Subset: AIM; IM |
Affiliation:
|
Pediatric Pathology, Department of Pathology, University Hospital, Zurich, Switzerland. thomas.stallmach@pty.usz.ch |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Female Fetal Death / epidemiology*, etiology* Humans Incidence Infant, Newborn Placenta / pathology, physiopathology* Pregnancy Questionnaires Recurrence Switzerland / epidemiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Interval between fetal measurements in predicting growth restriction.
Next Document: Immunologic studies in presumed amniotic fluid embolism.