Document Detail


Rescue by birth: defective placental maturation and late fetal mortality.
MedLine Citation:
PMID:  11275018     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To estimate the incidence and lethality of placental maturation defect, and to determine the impact of the pattern of placental dysfunction on the risk of recurrent stillbirth or maternal disease in later life. METHODS: Questionnaire and archival analysis of fetal deaths from placental dysfunction at 32-42 weeks (1975-1995 in Zurich), classified as chronic (parenchyma loss) or acute (maturation defect of the terminal chorionic villi). Population survey of 17,415 consecutive unselected singleton placentas (1994-1998 in Berlin). RESULTS: Of the 71 stillbirths, 34 were due to parenchyma loss and 37 to maturation defect. Parenchyma loss predominated in the first pregnancy (73.5% compared with 43.2%; P <.05). The risks of recurrent stillbirth and subsequent childlessness did not differ between the two groups. Eleven percent of mothers whose placenta had maturation defect had diabetes in the index pregnancy; none of the other women in the group developed diabetes over the 5-20-year observation period. In the population survey, incidence of maturation defect was 5.7%, and was associated with fetal death in 2.3% of cases. Normal placentas were associated with fetal death in 0.033%. CONCLUSION: Placental maturation defect can be a cause of fetal hypoxia. Although the risk of stillbirth is 70-fold that of a normal placenta, few affected fetuses actually die. The risk of recurrent stillbirth is tenfold above baseline and occurs mostly after 35 weeks' gestation.
Authors:
T Stallmach; G Hebisch; K Meier; J W Dudenhausen; M Vogel
Related Documents :
3024688 - Assessment of the datex relaxograph during anaesthesia and atracurium-induced neuromusc...
12499668 - Variability of autogamy-maturation pattern in genetically identical populations of para...
3946508 - Amniotic fluid phosphatidylglycerol and phosphatidylcholine phosphorus as predictors of...
3777858 - Functional phospholipid/sphingomyelin ratio: an easy to interpret indicator of fetal lu...
10206198 - Does ovulation induction affect the pregnancy rate after laparoscopic treatment of endo...
8194628 - Inhibition of angiotensin-converting enzyme--a new concept of medical treatment of male...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  97     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-03-29     Completed Date:  2001-04-26     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  505-9     Citation Subset:  AIM; IM    
Affiliation:
Pediatric Pathology, Department of Pathology, University Hospital, Zurich, Switzerland. thomas.stallmach@pty.usz.ch
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Female
Fetal Death / epidemiology*,  etiology*
Humans
Incidence
Infant, Newborn
Placenta / pathology,  physiopathology*
Pregnancy
Questionnaires
Recurrence
Switzerland / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Interval between fetal measurements in predicting growth restriction.
Next Document:  Immunologic studies in presumed amniotic fluid embolism.