Document Detail

Rescue Therapy With Romiplostim for Refractory Primary Immune Thrombocytopenia During Pregnancy.
MedLine Citation:
PMID:  25004319     Owner:  NLM     Status:  Publisher    
BACKGROUND:: Primary immune thrombocytopenia is not a rare event during pregnancy, and it must be carefully managed to avoid hemorrhagic complications for the mother. After failure of first-line treatments, the teratogenicity and toxicity of other therapeutic agents limit the available options and treatment.
CASES:: We describe the cases of two pregnant patients with corticosteroid-refractory immune thrombocytopenia who were successfully treated by romiplostim, a thrombopoietin receptor agonist, without any fetal or maternal complications.
CONCLUSION:: Romiplostim may represent an important alternative treatment choice during pregnancy for immune thrombocytopenia cases refractory to first-line therapy, especially because of its speed of action and high efficacy. Nevertheless, further data are required to provide definitive evidence of its safety for newborns.
Justine Decroocq; Louis Marcellin; Camille Le Ray; Lise Willems
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-7
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  -     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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