Document Detail


Resazurin microtiter assay plate: simple and inexpensive method for detection of drug resistance in Mycobacterium tuberculosis.
MedLine Citation:
PMID:  12121966     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A method for detecting multidrug-resistant Mycobacterium tuberculosis by using a reduction of resazurin is described. Eighty clinical isolates were evaluated against isoniazid and rifampin; results at 7 days were compared with those of the proportion method. Specificity and sensitivity were excellent. The method is simple, inexpensive, and rapid and might be used with other antituberculosis drugs.
Authors:
Juan-Carlos Palomino; Anandi Martin; Mirtha Camacho; Humberto Guerra; Jean Swings; Françoise Portaels
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  46     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-07-17     Completed Date:  2003-01-13     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2720-2     Citation Subset:  IM    
Affiliation:
Mycobacteriology Unit, Institute of Tropical Medicine, Nationalestraat 155, Antwerp 2000, Belgium. palomino@itg.be
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MeSH Terms
Descriptor/Qualifier:
Antitubercular Agents / pharmacology*
Colorimetry
Drug Resistance, Microbial
Humans
Indicators and Reagents
Isoniazid / pharmacology
Microbial Sensitivity Tests / methods*
Mycobacterium tuberculosis / drug effects*
Oxazines*
Peru
Rifampin / pharmacology
Tuberculosis / microbiology
Xanthenes*
Chemical
Reg. No./Substance:
0/Antitubercular Agents; 0/Indicators and Reagents; 0/Oxazines; 0/Xanthenes; 13292-46-1/Rifampin; 54-85-3/Isoniazid; 550-82-3/resazurin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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