Document Detail


Requirement of the spindle checkpoint for proper chromosome segregation in budding yeast meiosis.
MedLine Citation:
PMID:  10894778     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The spindle checkpoint was characterized in meiosis of budding yeast. In the absence of the checkpoint, the frequency of meiosis I missegregation increased with increasing chromosome length, reaching 19% for the longest chromosome. Meiosis I nondisjunction in spindle checkpoint mutants could be prevented by delaying the onset of anaphase. In a recombination-defective mutant (spo11Delta), the checkpoint delays the biochemical events of anaphase I, suggesting that chromosomes that are attached to microtubules but are not under tension can activate the spindle checkpoint. Spindle checkpoint mutants reduce the accuracy of chromosome segregation in meiosis I much more than that in meiosis II, suggesting that checkpoint defects may contribute to Down syndrome.
Authors:
M A Shonn; R McCarroll; A W Murray
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  289     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-07-25     Completed Date:  2000-07-25     Revised Date:  2007-03-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  300-3     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Department of Physiology, University of California, San Francisco, CA 94143-0444, USA.
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MeSH Terms
Descriptor/Qualifier:
Biomechanics
Chromosome Segregation / physiology*
Chromosomes, Fungal
Down Syndrome / genetics
Esterases / genetics
Kinetochores / physiology
Meiosis / genetics,  physiology*
Mitotic Spindle Apparatus / physiology*
Mutation
Nondisjunction, Genetic
Recombination, Genetic
Saccharomycetales / genetics,  physiology*
Spores, Fungal
Chemical
Reg. No./Substance:
0/Spo11 protein; EC 3.1.-/Esterases
Comments/Corrections
Comment In:
Science. 2000 Jul 14;289(5477):254-5   [PMID:  10917849 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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