Document Detail

Requirement for prooxidant and antioxidant states in T cell mediated immune responses.--Relevance for the pathogenetic mechanisms of AIDS?
MedLine Citation:
PMID:  1798289     Owner:  NLM     Status:  MEDLINE    
The discovery of decreased plasma cysteine and cystine levels and elevated plasma glutamate levels in HIV-infected patients has led to intense investigations into the role of cysteine in T cell-mediated immune responses. A large body of evidence indicates that certain aspects of the T cell response require the action of active oxygen derivatives while other aspects of the response require the action of antioxidants such as cysteine and glutathione (GSH). The prooxidant and antioxidant states may be required sequentially at different times during T cell activation. The extremely weak cystine transport activity of T cells together with oxidizing metabolites from inflammatory microenvironments appear to be important factors that support the prooxidant state. The relatively high cystine transport activity of the antigen-presenting macrophages, in contrast, provides these cells with a "cysteine pumping" function that allows the antigen binding T cells in their vicinity to shift to the antioxidant state. The difference between the membrane transport activities for cysteine of T cells and macrophages thus appears to be the key element of a mechanism that facilitates both, the prooxidant state of T cells and their regulated shift to the antioxidant state. When T cells do not receive sufficient amounts of cysteine, the intracellular GSH levels and rates of DNA synthesis activity decrease, and the cells may suffer from various manifestations of oxidative damage.(ABSTRACT TRUNCATED AT 250 WORDS)
W Dröge; H P Eck; H Gmünder; S Mihm
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Klinische Wochenschrift     Volume:  69     ISSN:  0023-2173     ISO Abbreviation:  Klin. Wochenschr.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-04-15     Completed Date:  1992-04-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  2985205R     Medline TA:  Klin Wochenschr     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  1118-22     Citation Subset:  IM; X    
Abteilung Immunchemie, Deutsches Krebsforschungszentrum, Heidelberg.
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MeSH Terms
Acquired Immunodeficiency Syndrome / immunology*
Cysteine / physiology*
Cystine / physiology
Free Radicals
Glutathione / physiology
Lymphocyte Activation / immunology*
Macrophage Activation / immunology
Oxygen / physiology*
T-Lymphocytes / immunology*
Reg. No./Substance:
0/Free Radicals; 52-90-4/Cysteine; 56-89-3/Cystine; 70-18-8/Glutathione; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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