Document Detail


Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3.
MedLine Citation:
PMID:  8940094     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
ALG-3, a truncated mouse homologue of the chromosome 1 familial Alzheimer's disease gene PS2, rescues T hybridoma 3DO cells from T-cell receptor-induced apoptosis by inhibiting Fas ligand induction and Fas signaling. Here we show that ALG-3 transfected 3DO cells express a COOH-terminal PS2 polypeptide. Overexpression of PS2 in ALG-3 transfected 3DO cells reconstitutes sensitivity to receptor-induced cell death, suggesting that the artificial PS2 polypeptide functions as a dominant negative mutant of PS2. ALG-3 and antisense PS2 protect PC12 cells from glutamate-induced apoptosis but not from death induced by hydrogen peroxide or the free radical MPP+. Thus, the PS2 gene is required for some forms of cell death in diverse cell types, and its function is opposed by ALG-3.
Authors:
P Vito; B Wolozin; J K Ganjei; K Iwasaki; E Lacanà; L D'Adamio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  271     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-01-09     Completed Date:  1997-01-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  31025-8     Citation Subset:  IM    
Affiliation:
T-Cell Molecular Biology Unit, Laboratory of Cellular and Molecular Immunology, NIAID, National Institutes of Health, Maryland 20892, USA. ldadamio@atlas.niaid.nih.gov
Data Bank Information
Bank Name/Acc. No.:
GENBANK/U49111;  U57324;  U57325
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / genetics*
Amino Acid Sequence
Animals
Apoptosis*
Humans
Membrane Proteins / metabolism*
Mice
Molecular Sequence Data
Presenilin-2
Sequence Alignment
Transfection
Chemical
Reg. No./Substance:
0/Membrane Proteins; 0/PSEN2 protein, human; 0/Presenilin-2; 0/Psen2 protein, mouse

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