Document Detail

Requirement for Twist1 in frontonasal and skull vault development in the mouse embryo.
MedLine Citation:
PMID:  19414008     Owner:  NLM     Status:  MEDLINE    
Using a Cre-mediated conditional deletion approach, we have dissected the function of Twist1 in the morphogenesis of the craniofacial skeleton. Loss of Twist1 in neural crest cells and their derivatives impairs skeletogenic differentiation and leads to the loss of bones of the snout, upper face and skull vault. While no anatomically recognizable maxilla is formed, a malformed mandible is present. Since Twist1 is expressed in the tissues of the maxillary eminence and the mandibular arch, this finding suggests that the requirement for Twist1 is not the same in all neural crest derivatives. The effect of the loss of Twist1 function is not restricted to neural crest-derived bones, since the predominantly mesoderm-derived parietal and interparietal bones are also affected, presumably as a consequence of lost interactions with neural crest-derived tissues. In contrast, the formation of other mesodermal skeletal derivatives such as the occipital bones and most of the chondrocranium are not affected by the loss of Twist1 in the neural crest cells.
Heidi Bildsoe; David A F Loebel; Vanessa J Jones; You-Tzung Chen; Richard R Behringer; Patrick P L Tam
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Publication Detail:
Type:  Journal Article     Date:  2009-05-03
Journal Detail:
Title:  Developmental biology     Volume:  331     ISSN:  1095-564X     ISO Abbreviation:  Dev. Biol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-29     Completed Date:  2009-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  176-88     Citation Subset:  IM    
Children's Medical Research Institute, The University of Sydney, Wentworthville, NSW, Australia.
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MeSH Terms
Branchial Region / cytology,  embryology,  physiology
Frontal Bone / embryology,  metabolism
Jaw / embryology,  metabolism
Mice, Mutant Strains
Morphogenesis / physiology*
Nasal Bone / embryology,  metabolism
Neural Crest / cytology,  embryology*,  physiology
Nuclear Proteins / physiology*
Skull / cytology,  embryology*,  physiology
Twist Transcription Factor / physiology*
Reg. No./Substance:
0/Nuclear Proteins; 0/Twist Transcription Factor; 136253-27-5/Twist1 protein, mouse

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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