| Required techniques and useful molecular markers in the neuropathologic diagnosis of neurodegenerative diseases. | |
MedLine Citation:
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PMID: 15645265 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Modern neuropathologic methods and molecular biology have lead to increased understanding of neurodegenerative disorders and biologically based classifications of these disorders. The purpose of this review is to discuss neuropathologic methods that are useful in the characterization of neurodegenerative disorders, with emphasis on disorders of late life that present with dementia or movement disorders. A diagnostic algorithm is suggested for neuropathologic evaluation of neurodegenerative disorders. The importance of clinical information is emphasized in arriving at the most precise and meaningful neuropathologic diagnosis. |
Authors:
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Dennis W Dickson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review Date: 2005-01-11 |
Journal Detail:
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Title: Acta neuropathologica Volume: 109 ISSN: 0001-6322 ISO Abbreviation: Acta Neuropathol. Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-02-15 Completed Date: 2005-06-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0412041 Medline TA: Acta Neuropathol Country: Germany |
Other Details:
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Languages: eng Pagination: 14-24 Citation Subset: IM |
Affiliation:
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Departments of Pathology (Neuropathology) and Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, 32224, USA. dickson.dennis@mayo.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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metabolism* Dementia / metabolism, pathology* Histocytochemistry / methods Humans Lewy Bodies / pathology Movement Disorders / metabolism, pathology* Neurodegenerative Diseases / metabolism, pathology* Neurofilament Proteins / metabolism Ubiquitin / metabolism tau Proteins / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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P01-AG03949/AG/NIA NIH HHS; P01-AG14449/AG/NIA NIH HHS; P01-AG17216/AG/NIA NIH HHS; P50-AG16574/AG/NIA NIH HHS; P50-NS40256/NS/NINDS NIH HHS; R01-AG19734/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Neurofilament Proteins; 0/Ubiquitin; 0/tau Proteins |
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