Document Detail


Required techniques and useful molecular markers in the neuropathologic diagnosis of neurodegenerative diseases.
MedLine Citation:
PMID:  15645265     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Modern neuropathologic methods and molecular biology have lead to increased understanding of neurodegenerative disorders and biologically based classifications of these disorders. The purpose of this review is to discuss neuropathologic methods that are useful in the characterization of neurodegenerative disorders, with emphasis on disorders of late life that present with dementia or movement disorders. A diagnostic algorithm is suggested for neuropathologic evaluation of neurodegenerative disorders. The importance of clinical information is emphasized in arriving at the most precise and meaningful neuropathologic diagnosis.
Authors:
Dennis W Dickson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review     Date:  2005-01-11
Journal Detail:
Title:  Acta neuropathologica     Volume:  109     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-02-15     Completed Date:  2005-06-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  14-24     Citation Subset:  IM    
Affiliation:
Departments of Pathology (Neuropathology) and Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, 32224, USA. dickson.dennis@mayo.edu
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / metabolism*
Dementia / metabolism,  pathology*
Histocytochemistry / methods
Humans
Lewy Bodies / pathology
Movement Disorders / metabolism,  pathology*
Neurodegenerative Diseases / metabolism,  pathology*
Neurofilament Proteins / metabolism
Ubiquitin / metabolism
tau Proteins / metabolism
Grant Support
ID/Acronym/Agency:
P01-AG03949/AG/NIA NIH HHS; P01-AG14449/AG/NIA NIH HHS; P01-AG17216/AG/NIA NIH HHS; P50-AG16574/AG/NIA NIH HHS; P50-NS40256/NS/NINDS NIH HHS; R01-AG19734/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Neurofilament Proteins; 0/Ubiquitin; 0/tau Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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