| Reprogramming somatic cell differentiation and the Hayflick Limit: contrasting two modern molecular bioengineering aims and their impact on the future of mankind. | |
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MedLine Citation:
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PMID: 11599467 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The molecular biology of human cloning and aging research depend on the closely related laboratory techniques supported by a thorough understanding of cell-signaling processes. Unfortunately, the link between these two research fields has received only marginal attention in the lay press. Cloning is possible when somatic cell differentiation is successfully reprogrammed, and clinical control of cellular senescence depends on a proper reconfiguration of the predetermined number of divisions permitted during the cell life-cycle (the so-called "Hayflick Limit"). In this paper, we discuss these two concepts and compare the impact likely to be associated with bioengineering studies that facilitate both human cloning and longevity therapy. |
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Authors:
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E S Sills; T Takeuchi; Z Rosenwaks; G D Palermo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of assisted reproduction and genetics Volume: 18 ISSN: 1058-0468 ISO Abbreviation: J. Assist. Reprod. Genet. Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-10-15 Completed Date: 2002-03-14 Revised Date: 2013-02-19 |
Medline Journal Info:
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Nlm Unique ID: 9206495 Medline TA: J Assist Reprod Genet Country: United States |
Other Details:
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Languages: eng Pagination: 468-70 Citation Subset: IM |
Affiliation:
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Georgia Reproductive Specialists LLC, Atlanta, Georgia, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Animals Cell Differentiation Cloning, Organism* Ethics* Humans Reproduction* Twins, Monozygotic |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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