Document Detail

Reprogramming somatic cell differentiation and the Hayflick Limit: contrasting two modern molecular bioengineering aims and their impact on the future of mankind.
MedLine Citation:
PMID:  11599467     Owner:  NLM     Status:  MEDLINE    
The molecular biology of human cloning and aging research depend on the closely related laboratory techniques supported by a thorough understanding of cell-signaling processes. Unfortunately, the link between these two research fields has received only marginal attention in the lay press. Cloning is possible when somatic cell differentiation is successfully reprogrammed, and clinical control of cellular senescence depends on a proper reconfiguration of the predetermined number of divisions permitted during the cell life-cycle (the so-called "Hayflick Limit"). In this paper, we discuss these two concepts and compare the impact likely to be associated with bioengineering studies that facilitate both human cloning and longevity therapy.
E S Sills; T Takeuchi; Z Rosenwaks; G D Palermo
Related Documents :
1722017 - Telomere loss: mitotic clock or genetic time bomb?
10339397 - Intramitotic and intraclonal variation in proliferative potential of human diploid cell...
20421597 - An mre11 mutation that promotes telomere recombination and an efficient bypass of senes...
17658517 - Inhibitory role of rhoa on senescence-like growth arrest by a mechanism involving modul...
18611147 - Assessment of the suitability of chitosan/polybutylene succinate scaffolds seeded with ...
1268847 - Resistance of human melanoma cells to ultraviolet radiation.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  18     ISSN:  1058-0468     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-10-15     Completed Date:  2002-03-14     Revised Date:  2013-02-19    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  468-70     Citation Subset:  IM    
Georgia Reproductive Specialists LLC, Atlanta, Georgia, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aging / physiology*
Cell Differentiation
Cloning, Organism*
Twins, Monozygotic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cloning in reproductive medicine.
Next Document:  Guillain-Barre syndrome. Experience in a third level hospital