| Reprogramming non-mammary and cancer cells in the developing mouse mammary gland. | |
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MedLine Citation:
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PMID: 22430755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The capacity of any portion of the murine mammary gland to produce a complete functional mammary outgrowth upon transplantation to an epithelium-divested fat pad is unaffected by the age or reproductive history of the donor. Likewise, through serial transplantations, no loss of potency is detected when compared to similar transplantations of the youngest mammary tissue tested. This demonstrates that stem cell activity is maintained intact throughout the lifetime of the animal despite aging and the repeated expansion and depletion of the mammary epithelium through multiple rounds of pregnancy, lactation and involution. These facts support the contention that mammary stem cells reside in protected tissue locales (niches), where their reproductive potency remains essentially unchanged through life. Disruption of the tissue, to produce dispersed cells results in the desecration of the protection afforded by the "niche" and leads to a reduced capacity of dispersed epithelial cells (in terms of the number transplanted) to recapitulate complete functional mammary structures. Our studies demonstrate that during the reformation of mammary stem cell niches by dispersed epithelial cells in the context of the intact epithelium-free mammary stroma, non-mammary cells, including mouse and human cancer cells, may be sequestered and reprogrammed to perform mammary epithelial cell functions including those ascribed to mammary stem/progenitor cells. |
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Authors:
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Robert D Bruno; Gilbert H Smith |
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Publication Detail:
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Type: Journal Article; Review Date: 2012-03-10 |
Journal Detail:
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Title: Seminars in cell & developmental biology Volume: 23 ISSN: 1096-3634 ISO Abbreviation: Semin. Cell Dev. Biol. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-07-16 Completed Date: 2012-10-15 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9607332 Medline TA: Semin Cell Dev Biol Country: England |
Other Details:
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Languages: eng Pagination: 591-8 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Ltd. |
Affiliation:
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Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Mammary Glands, Animal / cytology*, growth & development, metabolism* Mice Mice, Transgenic Neoplasms / metabolism*, pathology Nuclear Reprogramming* Stem Cells / cytology, metabolism |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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