| Reprogramming of liver to pancreas. | |
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MedLine Citation:
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PMID: 19089370 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Islet grafts have demonstrated that patients with diabetes would benefit greatly by beta-cell therapy. However, the paucity of available islets for transplantation as well as the immunological barriers faced in allogeneic transplantation represent a tremendous barrier to regenerative approaches to the treatment of diabetes. Here, we present a strategy and protocols to transdifferentiate developmentally related hepatocytes into beta-cells by the ectopic expression of critical beta-cell transcription factors. |
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Authors:
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Shifaan Thowfeequ; Wan-Chun Li; Jonathan M W Slack; David Tosh |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Methods in molecular biology (Clifton, N.J.) Volume: 482 ISSN: 1064-3745 ISO Abbreviation: Methods Mol. Biol. Publication Date: 2009 |
Date Detail:
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Created Date: 2008-12-17 Completed Date: 2009-02-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9214969 Medline TA: Methods Mol Biol Country: United States |
Other Details:
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Languages: eng Pagination: 407-18 Citation Subset: IM |
Affiliation:
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Centre for Regenerative Medicine, Department of Biology, University of Bath, Bath, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoviridae
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genetics Animals Cell Line Cell Separation Cells, Cultured Fluorescent Antibody Technique Gene Expression Regulation Hepatocytes / cytology, metabolism, virology Humans Liver / cytology, metabolism* Nuclear Reprogramming* Pancreas / cytology, metabolism* Rats Reverse Transcriptase Polymerase Chain Reaction Tissue Engineering / methods* Transfection |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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