Document Detail


Reprogramming Somatic Cells to a Kidney Fate.
MedLine Citation:
PMID:  25217274     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Recent years have challenged the view that adult somatic cells reach a state of terminal differentiation. Although the ultimate example of this, somatic cell nuclear transfer, has not proven feasible in human beings, dedifferentiation of mature cell types to a more primitive state, direct reprogramming from one mature state to another, and the reprogramming of any adult cell type to a pluripotent state via enforced expression of key transcription factors now all have been shown. The implications of these findings for kidney disease include the re-creation of key renal cell types from more readily available and expandable somatic cell sources. The feasibility of such an approach recently was shown with the dedifferentiation of proximal tubule cells to nephrogenic mesenchyme. In this review, we examine the technical and clinical challenges that remain to such an approach and how new reprogramming approaches also may be useful for kidney disease.
Authors:
Minoru Takasato; Jessica M Vanslambrouck; Melissa H Little
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Publication Detail:
Type:  REVIEW     Date:  2014-6-13
Journal Detail:
Title:  Seminars in nephrology     Volume:  34     ISSN:  1558-4488     ISO Abbreviation:  Semin. Nephrol.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-9-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8110298     Medline TA:  Semin Nephrol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  462-480     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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