Document Detail

Reproductive toxicity in male mice caused by organic extracts in tap water from the Jialing River in Chongqing, China.
MedLine Citation:
PMID:  21312319     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Recently, male reproductive disturbances caused by organic pollutants have aroused particular public concern about the safety of drinking water. The aim of this study was to investigate the toxicity of organic extracts (OE) in tap water from the source of the Jialing River in China on the reproductive system of male mice.
METHODS: Kunming male mice were randomly divided into four groups, which included a solvent control (dimethylsulfoxide), a low-, mid-, and high-dose of OE (12.5, 25, and 50 l/kg bw/day, respectively) treated groups. Mice were administered intraperitoneal injections of OE at different doses for five consecutive days. On the 15th day, after treatments, the mice were sacrificed.
RESULTS: The results showed that the number of epididymal sperm in the high OE group was decreased significantly (p<0.05); however, the frequency of sperm abnormalities in all treated groups were increased significantly (p<0.05). In addition, serum testosterone and follicle-stimulating hormone levels in the treated groups were also decreased significantly (p<0.05), and mid- and high-doses of OE resulted in a significant decrease in the activity of acid phosphatase and increased activity of γ-glutamyl transpeptidase (p<0.05). Histological changes were observed in the mid- and high-dose OE-treated groups.
CONCLUSIONS: The findings of this study suggest that mid and high doses of OE could disturb the male reproductive system in mice. The potential adverse effects of these compounds on the male reproductive system are worthy of further study. Birth Defects Res (Part B) 92:1-9, 2010. © 2011 Wiley-Liss, Inc.
Qing Zhao; Qian Ren; Ji-An Chen; Zhi-Qun Qiu; Jia Cao; Wei-Qun Shu
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Publication Detail:
Type:  Journal Article     Date:  2010-11-17
Journal Detail:
Title:  Birth defects research. Part B, Developmental and reproductive toxicology     Volume:  92     ISSN:  1542-9741     ISO Abbreviation:  Birth Defects Res. B Dev. Reprod. Toxicol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101155115     Medline TA:  Birth Defects Res B Dev Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-9     Citation Subset:  IM    
Copyright Information:
© 2010 Wiley-Liss, Inc.
Department of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, China.
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