| Reproductive status influences the survival of new cells in the dentate gyrus of adult male meadow voles. | |
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MedLine Citation:
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PMID: 12850539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reproductive status influences cell proliferation and the survival of new cells in the dentate gyrus of adult laboratory-reared and wild female meadow voles; reproductively inactive (RI) females have more proliferating cells and more labeled cells that survive 5 weeks vs. 2 h than reproductively active (RA) females. However, the effect of season has only been studied in a wild sample of male meadow voles and factors such as age and experience that have been shown to influence neurogenesis in the dentate gyrus of adult mammals cannot be controlled in a wild sample. Therefore, we investigated whether reproductive status regulates neurogenesis (cell proliferation and/or the survival of new cells) in the dentate gyrus of laboratory-reared adult male meadow voles so that confounding variables could be controlled. Males were acclimated to a short- or a long-photoperiod to simulate the non-breeding or breeding season, respectively, and reproductive status was verified by testes mass. The density of labeled cells was similar in RI and RA males (P=0.20) 2 h after an injection of bromodeoxyuridine (50 mg/kg) but the density of labeled cells was elevated in the RA males relative to the RI males 5 weeks after an injection of [(3)H]thymidine (5 microCi/g; P<or=0.04). The results suggest that reproductive status regulates the survival of new cells within the dentate gyrus of adult male meadow voles but not cell proliferation. |
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Authors:
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B K Ormerod; L A M Galea |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 346 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-07-09 Completed Date: 2003-09-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 25-8 Citation Subset: IM |
Affiliation:
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Department of Psychology and Graduate Neuroscience Program, The University of British Columbia, Vancouver, V6T 1Z4, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arvicolinae / physiology* Cell Count / methods Cell Survival / physiology Dentate Gyrus / cytology*, physiology* Male Reproduction / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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