Document Detail

Reproductive state changes NADPH-diaphorase staining in the paraventricular and supraoptic nuclei of female rats.
MedLine Citation:
PMID:  8955957     Owner:  NLM     Status:  MEDLINE    
It has been demonstrated in guinea pigs that nitric oxide synthase (NOS) activity is increased in late pregnancy in some peripheral tissues and in the cerebellum. To determine whether similar changes would be observed in areas of the brain known to play a role in parturition, staining for NADPH-diaphorase, a histochemical marker of NOS synthase, in the paraventricular (PVN) and supraoptic nuclei (SON) was compared among ovariectomized, virgin and late pregnant rats. The number of cells showing dense staining for NADPH-diaphorase increased in both the SON and PVN in late pregnancy compared to that observed in virgin and ovariectomized females. Thus, changes in reproductive state are associated with changes in NADPH-diaphorase staining in areas of the brain that are intimately involved in the control of reproductive function.
B Woodside; S Amir
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  739     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-04-01     Completed Date:  1997-04-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  339-42     Citation Subset:  IM    
Department of Psychology, Concordia University, Montreal, Qué., Canada.
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MeSH Terms
Estrus / metabolism*
NADPH Dehydrogenase / analysis*
Nitric Oxide Synthase / analysis
Ovary / physiology*
Paraventricular Hypothalamic Nucleus / enzymology*
Pregnancy, Animal / metabolism*
Rats, Wistar
Staining and Labeling
Supraoptic Nucleus / enzymology*
Reg. No./Substance:
EC Oxide Synthase; EC Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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