Document Detail

Reproductive outcomes in recurrent pregnancy loss associated with a parental carrier of a structural chromosome rearrangement.
MedLine Citation:
PMID:  16396938     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Reproductive outcome studies of couples with a history of recurrent pregnancy loss (RPL) associated with a maternal or paternal carrier of a structural chromosome rearrangement are limited. Correlation of carrier status and cytogenetics of miscarriage specimens is critical to estimate subsequent pregnancy outcome. METHODS: Couples found to have a structural chromosome rearrangement were followed prospectively in a tertiary academic centre. Descriptive analysis and subsequent pregnancy outcomes were tabulated and compared to historic controls. RESULTS: In 1893 RPL couples, 51 carriers of a structural chromosome rearrangement were identified (2.7%). Overall, this cohort had a total of 273 documented pregnancies. Prior to evaluation, the mean maternal age at the time of delivery or miscarriage was 29.8 years and the live birth rate was 15%. Following evaluation and treatment of concomitant factors, there were 58 monitored pregnancies, with a live birth rate of 71%. Amniocentesis was performed on 22% of the ongoing pregnancies; all were diploid or balanced structural chromosome rearrangements. Thirty-six per cent of the miscarriages were found to have an unbalanced structural chromosome rearrangement. CONCLUSIONS: Following evaluation and management of RPL, the live birth rate for carriers of a structural chromosome rearrangement is highly encouraging at 71%, without the addition of assisted reproductive technology.
Mary D Stephenson; Sony Sierra
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Publication Detail:
Type:  Journal Article     Date:  2006-01-05
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  21     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-22     Completed Date:  2006-06-05     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  1076-82     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA.
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MeSH Terms
Abortion, Habitual / genetics*
Birth Rate
Chromosome Inversion*
Longitudinal Studies
Maternal Age
Pregnancy Outcome*
Prospective Studies
Translocation, Genetic*

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