Document Detail

Reproductive and neurobehavioral outcome of drinking purified water under magnesium deficiency in the rat's diet.
MedLine Citation:
PMID:  18276053     Owner:  NLM     Status:  MEDLINE    
Taking magnesium deficient diet and drinking soft water (including purified water, essentially mineral free) are common consumed in the world. The present study was conducted to assess the potential combined influence of maternal drinking purified water and taking magnesium deficient diet on postnatal development and behavior in the offspring of exposed rats. Sprague-Dawley (SD) rat were assigned to four groups: group 1 fed with control diet (Mg(2+) 0.4 g/kg) and control water (Mg(2+) 12.7 mg/L), group 2 fed with control diet and purified water (Mg(2+) 0.015 mg/L), group 3 fed with magnesium deficient diet (Mg(2+) 0.2 g/kg) and control water, group 4 fed with magnesium deficient diet and purified water from 5 weeks of age of the F0 generation to 3 weeks of the F1 generation, respectively. Reproductive and neurobehavioral parameters were measured. Maternal body weights significantly decreased during treatment (before mating) and lactation periods in the group fed with magnesium deficient diet and purified water. There were no significant differences of the reproductive outcome in the groups. Offspring's body weight, development of reflexes significantly reduced in the group 4. Although it was no significant difference in the four groups, the data showed a trend toward a decreased risk for offspring body weight, neurobehavioral development as follows: group 1>group 2>group 3>group 4. Therefore, purified water cannot obviously affect the reproductive outcome when magnesium is sufficient or half of the estimated average requirement (EAR) in the diet. However, drinking purified water can decrease maternal magnesium level slightly, induce offspring's development retardation, especially when the magnesium deficiency in the diet. Furthermore, magnesium deficiency in the diet (half of the EAR) can produce growth delay and reflex development retardation in F1-offspring. Therefore, drinking purified water should be carefully considered, especially for susceptible population.
Hui Zeng; Wei-qun Shu; Qing Zhao; Qiang Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-13
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  46     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-03-24     Completed Date:  2008-06-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1495-502     Citation Subset:  IM    
Department of Environmental Hygiene, College of Military Preventive Medicine, Third Military Medical University, Chongqing, China.
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MeSH Terms
Avoidance Learning / drug effects
Behavior, Animal / drug effects*
Body Weight
Bone and Bones / metabolism
Growth / drug effects
Hand Strength / physiology
Magnesium / blood,  metabolism
Magnesium Deficiency / physiopathology*,  psychology*
Maze Learning / drug effects
Memory / drug effects
Postural Balance / drug effects
Rats, Sprague-Dawley
Reproduction / drug effects*
Walking / physiology
Water / chemistry*
Reg. No./Substance:
7439-95-4/Magnesium; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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