Document Detail

Reproductive issues for adults with autosomal dominant polycystic kidney disease.
MedLine Citation:
PMID:  18215709     Owner:  NLM     Status:  MEDLINE    
Autosomal dominant polycystic kidney disease (ADPKD) is a common disorder. However, the consequences of ADPKD on male and female reproductive health are not widely known. Several abnormalities are found in men with ADPKD, including necrospermia, immotile sperm, seminal vesicle cysts, and ejaculatory duct cysts. Female fertility is not affected. Affected women with ADPKD and normal renal function have a high rate of successful uncomplicated pregnancies. Pregnant women with ADPKD with compromised kidney function should be monitored carefully for the development of hypertension and preeclampsia. Their fetuses should be examined sonographically for signs of uteroplacental insufficiency, such as intrauterine growth restriction and oligohydramnios. The diagnosis of ADPKD should always be considered when prenatal sonographic findings of hyperechogenic enlarged kidneys are found. In this setting, a family history and renal sonogram of both parents is indicated. Sequencing of the PKD1 and PKD2 genes is available and can be used for both prenatal and preimplantation genetic diagnosis. We review in detail these topics to familiarize physicians taking care of patients with ADPKD with the reproductive issues that confront affected individuals.
Neeta Vora; Ronald Perrone; Diana W Bianchi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  51     ISSN:  1523-6838     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-24     Completed Date:  2008-02-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  307-18     Citation Subset:  IM    
Department of Pediatrics, Tufts-New England Medical Center and Floating Hospital for Children, Boston, MA 02111, USA.
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MeSH Terms
Age of Onset
Cysts / genetics
Fetal Growth Retardation / prevention & control
Genital Diseases, Male / genetics
Hypertension, Pregnancy-Induced / prevention & control
Infertility, Male / genetics,  physiopathology*
Kidney / ultrasonography
Oligohydramnios / prevention & control
Placental Circulation
Polycystic Kidney, Autosomal Dominant / genetics,  physiopathology*
Pre-Eclampsia / prevention & control
Pregnancy Complications / genetics,  physiopathology*
Preimplantation Diagnosis
Seminal Vesicles / pathology
Sequence Analysis, DNA
Spermatozoa / abnormalities
TRPP Cation Channels
Ultrasonography, Prenatal
Grant Support
Reg. No./Substance:
0/TRPP Cation Channels; 0/polycystic kidney disease 1 protein; 0/polycystic kidney disease 2 protein

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