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Reproductive immunology: biomarkers of compromised pregnancies.
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MedLine Citation:
PMID:  3319547     Owner:  NLM     Status:  MEDLINE    
The objective of this paper is to consider several categories of biomarkers of human pregnancy. The design of the report is to discuss useful and promising markers and techniques. Research gaps, needs, and priorities are also defined. Useful markers are mixed lymphocyte culture reactions, measures of lymphocytotoxic antibodies, histocompatibility (HLA) typing, and immunohematological evaluations. Promising markers are measures of major basic protein and early pregnancy factor, as well as determinations of trophoblast-lymphocyte cross-reactive (TLX) antigens. Promising techniques are fluorescence-activated cell-sorter analysis of maternal blood for fetal and extraembryonic tissues and immunotherapy with TLX and other antigens to prevent spontaneous abortion. It is concluded that immunology has much to offer the development of biomarkers of human pregnancy.
W P Faulk; C B Coulam; J A McIntyre
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Environmental health perspectives     Volume:  74     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-02-17     Completed Date:  1988-02-17     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  119-27     Citation Subset:  IM    
Methodist Center for Reproduction and Transplantation Immunology, Methodist Hospital of Indiana, Indianapolis 46202.
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MeSH Terms
Antibodies / immunology
Immunity, Cellular
Immunologic Techniques
Pregnancy / immunology*
Pregnancy Proteins / immunology
Trophoblasts / immunology
Reg. No./Substance:
0/Antibodies; 0/Pregnancy Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 10 Year: 1987
Volume: 74First Page: 119 Last Page: 127
ID: 1474495
PubMed Id: 3319547

Reproductive immunology: biomarkers of compromised pregnancies.
W P Faulk
C B Coulam
J A McIntyre
Methodist Center for Reproduction and Transplantation Immunology, Methodist Hospital of Indiana, Indianapolis 46202.

Article Categories:
  • Research Article

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